Kadcyla 100mg IV Inj. 1`s

A qualified oncology team administers it as an intravenous infusion every three weeks.

Kadcyla 100mg Injection Ingredients and Usage

Kadcyla 100mg Injection contains trastuzumab emtansine, an antibody-drug conjugate belonging to the targeted anticancer drug class. Oncologists prescribe it for HER2 positive metastatic breast cancer in patients previously treated with trastuzumab and taxane based chemotherapy.

Kadcyla 100mg Injection also treats early stage HER2 positive breast cancer in patients with residual invasive disease after neoadjuvant taxane and trastuzumab based treatment. Dosing is weight based, calculated at 3.6 mg per kilogram, and given once every three weeks. The 100mg vial allows precise dose adjustment alongside the 160mg vial for patients of varying body weight.

How Does Kadcyla 100mg Injection Work?

Kadcyla 100mg Injection combines trastuzumab, a monoclonal antibody that targets the HER2 receptor, with DM1, a potent microtubule inhibitor, joined by a stable chemical linker. Trastuzumab guides the conjugate directly to HER2 positive cancer cells.

Once bound to HER2, the conjugate is drawn inside the cancer cell, where it releases DM1 to disrupt microtubule function and block cell division. This targeted delivery concentrates the chemotherapy effect on cancer cells while limiting exposure to healthy tissue.

Kadcyla 100mg Injection Side Effects

Kadcyla 100mg Injection commonly causes fatigue, digestive, and blood related side effects. Regular monitoring during treatment is standard practice.

• Fatigue

• Nausea

• Musculoskeletal pain

• Low platelet count

• Headache

• Elevated liver enzymes

• Nosebleeds and easy bruising

Warnings

• Kadcyla 100mg Injection can cause serious hepatotoxicity, including liver failure and death; liver enzymes and bilirubin must be checked before starting treatment and before every dose.

• Nodular regenerative hyperplasia of the liver has been reported and can be fatal; treatment must be permanently stopped if this condition is diagnosed.

• The medicine can reduce left ventricular ejection fraction and lead to heart failure; cardiac function must be evaluated before and periodically during treatment.

• Exposure during pregnancy can cause embryo-fetal harm, including fatal lung underdevelopment in the baby; effective contraception is required during treatment and for a defined period after the last dose.

• Kadcyla is not interchangeable with trastuzumab; vial labels must be checked carefully before preparation and administration to prevent dangerous medication errors.

• The medicine can cause pulmonary toxicity, infusion related reactions, hemorrhage, and peripheral neuropathy; emergency equipment should be available during infusion in case of severe reactions.

• Avoid combining Kadcyla 100mg Injection with strong CYP3A4 inhibitors, such as voriconazole, since these can increase toxicity of the DM1 component.

Kadcyla 100mg Injection Storage Conditions

Store Kadcyla 100mg Injection refrigerated between 2°C and 8°C, and do not freeze or shake the vial. Protect the vial from light and keep it in its original carton until immediately before use. Store this medicine out of reach of children and ensure only trained healthcare staff handle preparation and administration.