Hepatitis B Immunoglobulin
| Manufacturer | Various Pharmaceutical Companies |
| Active Ingredients | Human Hepatitis B Immunoglobulin |
| Medicine Strength | 100-500 International Units per ml (various vial sizes) |
| Formulation | Solution for Intramuscular Injection |
| Requires Prescription? | Yes (Hospital/Clinic Administration - Physician prescription required) |
| Generics | HBIG, Hepatitis B Immune Globulin |
Hepatitis B Immunoglobulin Ingredients and Usage
The active ingredient is Human Hepatitis B Immunoglobulin, containing high titers of antibodies against Hepatitis B surface antigen (HBsAg). It is administered by deep intramuscular injection, typically in the gluteal region or deltoid muscle, as soon as possible after exposure and within 24 hours for optimal effectiveness.
Hepatitis B Immunoglobulin is clinically indicated for:
Post-exposure prophylaxis following needlestick or sharps exposure to HBsAg-positive material
Prevention of Hepatitis B infection in infants born to HBsAg-positive mothers
Sexual partners of individuals with acute Hepatitis B infection
Household contacts of individuals with acute Hepatitis B infection
Liver transplant recipients with Hepatitis B
How Does Hepatitis B Immunoglobulin Work?
Hepatitis B Immunoglobulin provides immediate passive immunity through antibody transfer:
Virus Neutralization: Provides ready-made antibodies that neutralize Hepatitis B virus
Immediate Protection: Offers instant immunity while Hepatitis B vaccine develops active immunity
Infection Prevention: Prevents establishment of Hepatitis B infection after exposure
Bridge Protection: Protects during the critical period until vaccine-induced immunity develops
Hepatitis B Immunoglobulin Side Effects and Warnings
Common side effects include pain and tenderness at injection site, headache, fever, chills, and malaise. Most reactions are mild and transient.
Serious Considerations
Anaphylaxis Risk: May cause severe allergic reactions in sensitive individuals
IGA Deficiency: Contraindicated in patients with selective IgA deficiency
Thrombocytopenia: Use with caution in patients with thrombocytopenia or bleeding disorders
Vaccine Interference: Does not interfere with active immunization by Hepatitis B vaccine
Multiple Injections: Large doses may require divided injections at different sites
Hepatitis B Immunoglobulin Storage Conditions
Hepatitis B Immunoglobulin requires strict storage conditions:
Store at 2°C to 8°C in refrigerator
Do not freeze - protect from light
Keep in original carton until use
Do not use if cloudy or contains particles
Use immediately after opening
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