Dopamine Injection 200mg/5ml

Manufacturer	Abbott Laboratories Pakistan
Active Ingredients	Dopamine Hydrochloride
Medicine Strength	200mg per 5mL vial (40mg/mL)
Formulation	Concentrate for Intravenous Infusion
Requires Prescription?	Yes (ICU/Critical Care use only)
Generics	Dopamine

Dopamine Ingredients and Usage

The active ingredient is Dopamine Hydrochloride, a natural catecholamine and neurotransmitter. The 200mg concentrate requires dilution before continuous intravenous infusion with precise rate control. Dopamine is clinically indicated for:

• Cardiogenic shock and heart failure
• Hypotension unresponsive to fluid resuscitation
• Low cardiac output states
• Renal perfusion enhancement in specific doses

How Does Dopamine Work?

Dopamine provides dose-dependent cardiovascular effects through receptor activation:

1. Renal Vasodilation: Low doses activate dopamine receptors improving renal blood flow
2. Cardiac Stimulation: Moderate doses stimulate beta-1 receptors increasing contractility
3. Vasoconstriction: High doses activate alpha receptors increasing blood pressure
4. Neurotransmitter Action: Natural precursor to norepinephrine and epinephrine

Dopamine Side Effects and Warnings

Common side effects include tachycardia, arrhythmias, hypertension, and peripheral vasoconstriction. Most effects are dose-related and require careful monitoring.

Serious Considerations

1. Extravasation Risk: Causes severe tissue necrosis requiring phentolamine infiltration
2. Arrhythmia Potential: Requires continuous cardiac monitoring during infusion
3. Dose Titration: Precise infusion pump control essential for safety
4. Drug Interactions: MAO inhibitors require significant dose reduction
5. Peripheral Ischemia: Monitor for decreased perfusion in extremities

Dopamine Storage Conditions

Dopamine Injection requires careful storage handling:

• Store at room temperature below 25°C
• Protect from light - solution may discolor upon exposure
• Use diluted solution within 24 hours
• Discard if solution appears discolored pink, brown, or contains particles
• Follow strict aseptic preparation techniques