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Dasirox Tablets 250 mg 30 Tablets
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Overview
| Manufacturer | Getz Pharma Pakistan |
| Active Ingredients | Deferasirox |
| Medicine Strength | 250mg per Tablet |
| Formulation | Film-Coated Tablets |
| Requires Prescription? | Yes (Hematologist prescription required) |
| Generics | Deferasirox |
Dasirox Ingredients and Usage
The active ingredient is Deferasirox, a tridentate oral iron chelating agent. The 250mg tablet is taken once daily on an empty stomach 30 minutes before food.
Dasirox is clinically indicated for:
- Chronic iron overload in transfusion-dependent patients
- Thalassemia major with iron accumulation
- Sickle cell disease patients requiring iron chelation
- Other chronic anemias with transfusion iron overload
How Does Dasirox Work?
Dasirox provides selective iron removal through specific chelation mechanisms:
- Selective Iron Binding: High affinity for iron molecules
- Complex Formation: Creates stable iron-deferasirox complexes
- Biliary Excretion: Eliminates iron primarily through feces
- Dose-Dependent Action: Chelation efficiency increases with dosage
Dasirox Side Effects and Warnings
Common side effects include nausea, diarrhea, abdominal pain, and skin rash. Most effects are mild to moderate and dose-dependent.
Serious Considerations
- Renal Function: Monitor serum creatinine and creatinine clearance
- Hepatic Monitoring: Regular liver function tests required
- GI Complications: Risk of ulcers and gastrointestinal hemorrhage
- Auditory Changes: Monitor for hearing loss and vision disturbances
- Blood Tests: Regular serum ferritin and iron studies essential
Dasirox Storage Conditions
Dasirox Tablets require proper storage conditions:
- Store at room temperature below 30°C
- Keep in original blister packaging
- Protect from moisture and light
- Keep out of reach of children
- Do not use after expiration date
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