Dasirox 400mg Tablets 30S

Manufacturer	Getz Pharma Pakistan
Active Ingredients	Deferasirox
Medicine Strength	400mg per Tablet
Formulation	Film-Coated Tablets
Requires Prescription?	Yes (Hematologist prescription required)
Generics	Deferasirox

Dasirox Ingredients and Usage

The active ingredient is Deferasirox, a tridentate oral iron chelator. The 400mg tablet is taken once daily on an empty stomach at least 30 minutes before food. Dasirox is clinically indicated for:

• Chronic iron overload due to blood transfusions
• Thalassemia major patients
• Sickle cell disease with iron overload
• Other transfusion-dependent anemias

How Does Dasirox Work?

Dasirox provides selective iron removal through chelation mechanisms:

1. Iron Binding: Selectively binds to iron with high affinity
2. Complex Formation: Forms stable 2:1 complex with iron molecules
3. Fecal Excretion: Eliminates iron through biliary and fecal routes
4. Selective Action: Preferentially binds excess iron over essential iron

Dasirox Side Effects and Warnings

Common side effects include gastrointestinal disturbances, skin rash, and mild creatinine elevation. Most effects are manageable with dose adjustment.

Serious Considerations

1. Renal Impairment: Monitor serum creatinine regularly
2. Hepatic Toxicity: Regular liver function tests required
3. GI Hemorrhage: Risk of gastrointestinal ulceration and bleeding
4. Auditory Changes: May cause hearing loss and vision disturbances
5. Blood Monitoring: Regular serum ferritin and iron studies needed

Dasirox Storage Conditions

Dasirox Tablets require proper storage conditions:

• Store at room temperature below 30°C
• Keep in original packaging protected from moisture
• Protect from light and excessive heat
• Keep out of reach of children
• Do not use after expiration date