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Dasirox 500 mg Tablet 30's
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Overview
| Manufacturer | Getz Pharma Pakistan |
| Active Ingredients | Deferasirox |
| Medicine Strength | 500mg per Tablet |
| Formulation | Film-Coated Tablets |
| Requires Prescription? | Yes (Hematologist prescription required) |
| Generics | Deferasirox |
Dasirox Ingredients and Usage
The active ingredient is Deferasirox, a tridentate oral iron chelating agent. The 500mg tablet is taken once daily on an empty stomach 30 minutes before food for optimal absorption.
Dasirox is clinically indicated for:
- Severe chronic iron overload in transfusion-dependent patients
- Thalassemia major with high iron burden
- Patients requiring aggressive iron chelation therapy
- Transfusion-dependent anemias with elevated serum ferritin
How Does Dasirox Work?
Dasirox provides potent iron removal through enhanced chelation mechanisms:
- High-Capacity Binding: Increased iron binding capacity with higher dose
- Stable Complex Formation: Forms 2:1 deferasirox-iron complexes
- Efficient Excretion: Enhanced fecal elimination of iron complexes
- Selective Action: Preferentially targets non-transferrin bound iron
Dasirox Side Effects and Warnings
Common side effects include gastrointestinal disturbances, skin rash, headache, and proteinuria. Most effects are dose-dependent and manageable.
Serious Considerations
- Renal Monitoring: Enhanced surveillance for creatinine elevation
- Hepatic Function: Close monitoring of liver enzymes required
- GI Safety: Increased risk of gastrointestinal ulcers and bleeding
- Auditory Changes: Regular hearing and vision assessments needed
- Dose Adjustment: Based on serum ferritin trends and safety parameters
Dasirox Storage Conditions
Dasirox Tablets require proper storage conditions:
- Store at room temperature below 30°C
- Keep in original packaging protected from moisture
- Protect from light and excessive heat
- Keep out of reach of children
- Do not use after expiration date
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