Dasirox 500 mg Tablet 30's

Manufacturer	Getz Pharma Pakistan
Active Ingredients	Deferasirox
Medicine Strength	500mg per Tablet
Formulation	Film-Coated Tablets
Requires Prescription?	Yes (Hematologist prescription required)
Generics	Deferasirox

Dasirox Ingredients and Usage

The active ingredient is Deferasirox, a tridentate oral iron chelating agent. The 500mg tablet is taken once daily on an empty stomach 30 minutes before food for optimal absorption. Dasirox is clinically indicated for:

• Severe chronic iron overload in transfusion-dependent patients
• Thalassemia major with high iron burden
• Patients requiring aggressive iron chelation therapy
• Transfusion-dependent anemias with elevated serum ferritin

How Does Dasirox Work?

Dasirox provides potent iron removal through enhanced chelation mechanisms:

1. High-Capacity Binding: Increased iron binding capacity with higher dose
2. Stable Complex Formation: Forms 2:1 deferasirox-iron complexes
3. Efficient Excretion: Enhanced fecal elimination of iron complexes
4. Selective Action: Preferentially targets non-transferrin bound iron

Dasirox Side Effects and Warnings

Common side effects include gastrointestinal disturbances, skin rash, headache, and proteinuria. Most effects are dose-dependent and manageable.

Serious Considerations

1. Renal Monitoring: Enhanced surveillance for creatinine elevation
2. Hepatic Function: Close monitoring of liver enzymes required
3. GI Safety: Increased risk of gastrointestinal ulcers and bleeding
4. Auditory Changes: Regular hearing and vision assessments needed
5. Dose Adjustment: Based on serum ferritin trends and safety parameters

Dasirox Storage Conditions

Dasirox Tablets require proper storage conditions:

• Store at room temperature below 30°C
• Keep in original packaging protected from moisture
• Protect from light and excessive heat
• Keep out of reach of children
• Do not use after expiration date