Temorel 20mg Capsules

Doctors prescribe it for glioblastoma and anaplastic astrocytoma in adults and children over three years

Temorel 20mg Capsules Ingredients and Usage

Temorel 20mg Capsules contain temozolomide, a second generation alkylating agent from the imidazotetrazine drug class. Alkylating agents attach chemical groups to tumour DNA, which halts cancer cell division and growth. Oncologists prescribe Temorel for malignant brain tumours that grow and spread quickly.

Temorel treats newly diagnosed glioblastoma multiforme, a fast growing brain tumour, alongside radiotherapy and as maintenance therapy. It also treats anaplastic astrocytoma that returns or worsens after standard treatment. Temozolomide crosses the blood brain barrier, which lets it reach tumours inside the central nervous system.

How Does Temorel 20mg Capsules Work?

Temorel 20mg Capsules work because temozolomide is a prodrug that converts to its active form MTIC at body pH. MTIC releases a reactive methyl group that attaches to tumour DNA at the O6 position of guanine, a building block of DNA. This O6 methylguanine lesion is the main cytotoxic damage that drives the drug effect.

The damaged guanine pairs incorrectly with thymine during DNA copying, which triggers the mismatch repair system. Repeated failed repair cycles produce DNA breaks that push the cancer cell into apoptosis, a controlled cell death. Tumours with high MGMT enzyme levels repair this damage and resist temozolomide.

Temorel 20mg Capsules Side Effects

Temorel 20mg Capsules commonly cause digestive and general symptoms because chemotherapy affects rapidly dividing healthy cells. Report severe or persistent effects to your oncologist promptly.

• Nausea and vomiting

• Fatigue and weakness

• Constipation or diarrhoea

• Headache

• Loss of appetite

• Hair thinning or loss

• Skin rash

• Seizures or convulsions

Warnings

• Temorel can cause myelosuppression, a drop in blood cells that includes leukopenia, anaemia, and rarely fatal aplastic anaemia.

• Doctors must not give Temorel to patients allergic to temozolomide or dacarbazine, since both form the same active metabolite MTIC.

• Temozolomide harms the unborn baby, so females of reproductive age must use effective contraception during treatment and for six months after.

• Geriatric patients and women face a higher risk of severe blood cell suppression during therapy.

• Temorel raises the risk of Pneumocystis pneumonia, a serious lung infection, especially in patients taking steroids.

• Fatal and severe liver toxicity have occurred, so doctors monitor liver function during treatment.

Temorel 20mg Capsules Storage Conditions

Store Temorel 20mg Capsules at room temperature near 25°C, with short excursions permitted between 15°C and 30°C. Keep the capsules in their original sealed container, away from direct light and excess humidity, since temozolomide degrades in moist conditions. Store the medicine out of reach of children, because this potent chemotherapy drug is harmful if swallowed accidentally.