Stivant 100 mg Injection

This biosimilar antibody starves tumours by blocking the blood vessels that feed them.

Stivant 100mg Injection Ingredients and Usage

Stivant 100mg Injection contains bevacizumab, a recombinant humanized monoclonal antibody from the antiangiogenic drug class. Antiangiogenic agents block the growth of new blood vessels that tumours need to survive. Oncologists prescribe Stivant for metastatic colorectal cancer, often combined with fluorouracil based chemotherapy.

Stivant also treats recurrent glioblastoma, non small cell lung cancer, and metastatic renal cell carcinoma. Doctors use Stivant for advanced cervical cancer and for ovarian, fallopian tube, and peritoneal cancers. A healthcare professional gives Stivant as a slow intravenous infusion every 2 to 3 weeks.

How Does Stivant 100mg Injection Work?

Stivant works by binding to vascular endothelial growth factor A, known as VEGF-A. VEGF-A is a protein that signals the body to grow new blood vessels toward a tumour. By trapping this protein, Stivant stops it from reaching its targets.

Stivant blocks VEGF-A from binding its receptors, VEGFR-1 and VEGFR-2, on the surface of blood vessel cells. This action halts angiogenesis, the formation of new blood vessels that supply oxygen and nutrients. As a result, Stivant cuts off the tumour blood supply and slows cancer growth and spread.

Stivant 100mg Injection Side Effects

Stivant commonly raises blood pressure and may cause protein loss in the urine. Most side effects are mild to moderate, though some require monitoring or treatment.

• High blood pressure (hypertension)

• Protein in the urine (proteinuria)

• Fatigue and headache

• Nosebleeds and minor bleeding

• Diarrhea, nausea, and vomiting

• Changes in taste

• Mouth sores and dry skin

Warnings

• Stivant carries a boxed warning for gastrointestinal perforation, a tear in the stomach or bowel wall that occurs in up to 2.4 percent of patients.

• Stivant carries a boxed warning for serious hemorrhage, so doctors avoid it in patients with recent bleeding or coughing up blood.

• Stivant impairs wound healing, so treatment must stop before planned surgery and resume only after full recovery.

• Stivant raises the risk of blood clots, including arterial clots that can cause stroke or heart attack.

• Stivant can harm the fetus, so patients must avoid pregnancy and use contraception during treatment.

• Doctors monitor blood pressure and urine protein during treatment and may pause Stivant for severe hypertension or kidney problems.

Stivant 100mg Injection Storage Conditions

Store Stivant vials in a refrigerator at 2°C to 8°C in the original carton to protect the solution from light. Never freeze or shake Stivant, as both actions damage the bevacizumab antibody and make the medicine unsafe. Keep the vial out of the reach of children, and let a healthcare professional handle dilution and storage of the prepared infusion.