PharmaCristine 2mg/2ml IV Inj. 1`s

This medicine is for intravenous use only and must be administered by a trained oncology professional..

PharmaCristine 2mg/2ml IV Injection Ingredients and Usage

PharmaCristine 2mg/2ml IV Injection contains vincristine sulphate, a vinca alkaloid belonging to the plant derived antineoplastic drug class. Oncologists prescribe it for leukemias, lymphomas, and solid tumors including neuroblastoma, Wilms tumor, breast cancer, and lung cancer.

PharmaCristine 2mg/2ml IV Injection is typically combined with other chemotherapy agents as part of a wider treatment protocol. Dosing is calculated by body surface area, and a maximum single dose limit is enforced to reduce the risk of severe nerve damage.

How Does PharmaCristine 2mg/2ml IV Injection Work?

Vincristine binds with high affinity to tubulin, the protein subunit that forms microtubules. This binding blocks the polymerization of tubulin needed to build the mitotic spindle during cell division.

By disrupting the mitotic spindle, PharmaCristine 2mg/2ml IV Injection arrests cancer cells in the metaphase stage of division. This halts chromosome segregation and triggers programmed cell death, slowing or stopping tumor growth.

PharmaCristine 2mg/2ml IV Injection Side Effects

PharmaCristine 2mg/2ml IV Injection commonly causes nerve related and digestive side effects. Peripheral neuropathy is dose limiting and often requires close monitoring.

• Numbness, tingling, or weakness in hands and feet

• Constipation, which can progress to bowel obstruction if untreated

• Jaw pain

• Hair loss

• Muscle cramps

• Low blood pressure

• Headache

Warnings

• PharmaCristine 2mg/2ml IV Injection is for intravenous use only. Administration into the spinal fluid is fatal and this route must never be used under any circumstances.

• Every syringe must be clearly labeled "for IV use only" and handled with strict verification protocols to prevent confusion with drugs intended for spinal injection.

• The medicine can leak into surrounding tissue during infusion, causing severe irritation or tissue damage at the injection site.

• Avoid use in patients with pre-existing neuromuscular disease, such as Charcot Marie Tooth syndrome, due to the risk of worsening nerve damage.

• PharmaCristine 2mg/2ml IV Injection is not recommended in pregnancy or breastfeeding unless absolutely necessary; discuss risks and benefits with a specialist.

• Monitor for constipation and bowel function throughout treatment, since severe cases can progress to paralytic ileus.

• Dose adjustment is required in patients with liver impairment, since vincristine is eliminated primarily through the biliary route.

PharmaCristine 2mg/2ml IV Injection Storage Conditions

Store PharmaCristine 2mg/2ml IV Injection refrigerated between 2°C and 8°C, and do not freeze the vial. Protect the vial from light and keep it in its original carton until immediately before use. Store this medicine out of reach of children, and ensure only trained oncology staff handle preparation, labeling, and administration.