Nitonib 150mg Caps. 120`s

Doctors prescribe it for newly diagnosed patients and those who no longer respond to imatinib.

Nitonib 150mg Capsules Ingredients and Usage

Nitonib 150mg Capsules contain nilotinib, a tyrosine kinase inhibitor belonging to the targeted anticancer drug class. Doctors prescribe it for Philadelphia chromosome positive chronic myeloid leukemia, a blood cancer driven by the BCR ABL fusion gene.

Physicians use Nitonib 150mg Capsules in newly diagnosed chronic phase patients and in those with chronic or accelerated phase disease who no longer respond to or tolerate imatinib. A specialist experienced in leukemia treatment should initiate and monitor therapy throughout the course.

How Does Nitonib 150mg Capsules Work?

Nilotinib blocks the tyrosine kinase activity of the abnormal BCR ABL protein produced by the Philadelphia chromosome. This protein normally signals white blood cells to multiply uncontrollably in chronic myeloid leukemia.

Nitonib 150mg Capsules bind the ATP pocket of BCR ABL with higher affinity than older therapies, overriding resistance caused by common gene mutations. By halting this signal, the medicine stops leukemic cell multiplication and triggers cancer cell death over weeks to months of treatment.

Nitonib 150mg Capsules Side Effects

Nitonib 150mg Capsules commonly cause digestive and skin related side effects. Most cases are mild and ease as treatment continues.

• Nausea and vomiting

• Headache

• Abdominal pain and constipation

• Skin rash and itching

• Muscle and joint pain

• Fatigue

• Hair loss

Warnings

• Nitonib 150mg Capsules can prolong the QT interval and carry a boxed warning for sudden cardiac death; a baseline ECG is required before starting treatment.

• Avoid Nitonib 150mg Capsules in patients with low potassium, low magnesium, or a history of QT prolongation, since these raise the risk of fatal heart rhythm changes.

• Never combine Nitonib 150mg Capsules with strong CYP3A4 inhibitors, such as certain antifungals, or with other QT prolonging drugs including some antiarrhythmics and antipsychotics.

• Take Nitonib 150mg Capsules on an empty stomach, since food significantly increases nilotinib absorption and raises toxicity risk. Avoid food for at least 2 hours before and 1 hour after each dose.

• Regular complete blood counts are required, as the medicine can cause severe neutropenia, thrombocytopenia, and anemia.

• Avoid use in pregnancy and breastfeeding; use effective contraception during treatment and for two weeks after the last dose.

• Monitor liver function and blood glucose periodically, since Nitonib 150mg Capsules can affect both.

Nitonib 150mg Capsules Storage Conditions

Store Nitonib 150mg Capsules at 20°C to 25°C, with brief excursions between 15°C and 30°C considered acceptable. Keep capsules in their original blister pack, away from direct light and moisture, and avoid refrigeration. Store this medicine out of reach of children, since accidental ingestion of an anticancer drug can cause serious harm.