Axinix (Axitinib) 5mg Tablet

Doctors prescribe it as a twice daily tablet, taken with or without food.

Axinix 5mg Tablet Ingredients and Usage

Axinix 5mg Tablet contains axitinib, a small molecule kinase inhibitor belonging to the targeted anticancer drug class. Doctors prescribe it for advanced renal cell carcinoma in patients whose disease has progressed after one prior systemic therapy.

Axinix 5mg Tablet is taken twice daily, approximately 12 hours apart, swallowed whole with a glass of water. Dose adjustments upward or downward are common during treatment based on individual tolerability, and therapy is guided by an oncologist experienced in kidney cancer treatment.

How Does Axinix 5mg Tablet Work?

Axitinib inhibits vascular endothelial growth factor receptors 1, 2, and 3, proteins that drive the formation of new blood vessels feeding a tumor. This process, called angiogenesis, is essential for tumor growth and spread.

By blocking these receptors, Axinix 5mg Tablet starves the tumor of the blood supply it needs to grow and inhibits the signaling pathways that promote cancer cell survival. This targeted mechanism underlies its activity specifically in kidney cancer, which is highly dependent on angiogenesis.

Axinix 5mg Tablet Side Effects

Axinix 5mg Tablet commonly causes digestive, blood pressure, and general side effects.

• Diarrhea

• High blood pressure

• Fatigue

• Decreased appetite

• Nausea and vomiting

• Hoarseness or voice changes

• Hand-foot skin reaction

Warnings

• Axinix 5mg Tablet commonly causes hypertension, sometimes severe; blood pressure must be well controlled before starting treatment and monitored regularly throughout.

• The medicine increases the risk of serious bleeding events; use with caution in patients with a history of hemorrhage or untreated brain metastases.

• Axinix 5mg Tablet raises the risk of blood clots, including arterial and venous thromboembolic events such as stroke, heart attack, and pulmonary embolism.

• Gastrointestinal perforation and fistula formation have been reported; report severe abdominal pain promptly.

• Axinix 5mg Tablet is contraindicated in pregnancy, since it can cause fetal harm; effective contraception is required during treatment.

• Treatment should be withheld at least 24 hours before scheduled surgery, since axitinib can impair wound healing.

• Avoid strong CYP3A4/5 inhibitors and inducers, including certain antifungals, antibiotics, and anticonvulsants, since these significantly alter axitinib blood levels; a lower starting dose is required in moderate liver impairment.

Axinix 5mg Tablet Storage Conditions

Store Axinix 5mg Tablet in a cool, dry place, away from direct light. Keep tablets in their original packaging until the dose is due. Store this medicine out of reach of children and dispose of any expired or unused tablets according to local pharmacy guidelines.