Axinix (Axitinib) 5mg Tablet
Axinix 5mg Tablet contains axitinib, an oral tyrosine kinase inhibitor used to treat advanced renal cell carcinoma after failure of one prior systemic therapy. Buy Axinix 5mg Tablet at PakMeds with a valid prescription.
Axinix 5mg Tablet Ingredients and Usage
Axinix 5mg tablets contains axitinib, a small molecule kinase inhibitor belonging to the targeted anticancer drug class. Axinix is used primarily for advanced renal cell carcinoma (kidney cancer) in patients whose disease has progressed after one prior systemic therapy.
Axinix 5mg tablet is taken twice daily, approximately 12 hours apart, swallowed whole with a glass of water. Dose adjustments upward or downward are common during treatment based on individual tolerability, and therapy is guided by an oncologist experienced in kidney cancer treatment.
How Does Axinix 5mg Tablet Work?
According to the NCBI, Axitinib inhibits vascular endothelial growth factor receptors (VEGFR) 1, 2, and 3. These are proteins that drive the formation of new blood vessels feeding a tumor. This formation of new capillaries from older ones is called angiogenesis, and is essential for tumor growth and spread.
By blocking these receptors, Axinix 5mg tablets starve the tumor of the blood supply it needs to grow. This in turn inhibits the signaling pathways that promote cancer cell survival. This targeted mechanism underlies its activity specifically in kidney cancer, which is highly dependent on angiogenesis.
In even simpler words, renal cell carcinoma needs new blood supply. Axitinib binds to the control panel that controls the supply station of new capillaries and starves the cancer.
Axinix 5mg Tablet Side Effects
Axinix interacts with VEGFR 1,2, & 3, which can cause multiple side effects. Most of these side effects are related to blood flow, nutrition, and heart problems. Some side effects of Axinix 5mg are:
Diarrhea
High blood pressure
Fatigue
Decreased appetite
Nausea and vomiting
Hoarseness or voice changes
Hand-foot skin reaction
Warnings
Axinix 5mg Tablet commonly causes hypertension, sometimes severe. Blood pressure must be well controlled before starting treatment and monitored regularly throughout.
The medicine increases the risk of serious bleeding events; use with caution in patients with a history of hemorrhage or untreated brain metastases.
Axinix 5mg Tablet raises the risk of blood clots, including arterial and venous thromboembolic events such as stroke, heart attack, and pulmonary embolism.
Gastrointestinal perforation and fistula formation have been reported, some patients report severe abdominal pain promptly.
Axinix 5mg Tablet is contraindicated in pregnancy, since it can cause fetal harm; effective contraception is required during treatment.
Treatment should be withheld at least 24 hours before scheduled surgery, since axitinib can impair wound healing.
Avoid strong CYP3A4/5 inhibitors and inducers, including certain antifungals, antibiotics, and anticonvulsants, since these significantly alter axitinib blood levels.
Please consult a doctor if you feel any of these or other side-effects. Only a licensed oncologist can provide valuable insights on your treatment, symptoms, side-effects, and potential solutions.
Axinix 5mg Tablet Storage Conditions
Store Axinix 5mg Tablets in a cool, dry place, away from direct light. Keep tablets in their original packaging until the dose is due. Store this medicine out of reach of children and dispose of any expired or unused tablets according to local pharmacy guidelines.
FAQs on Axinix (Axitinib)
Is Axitinib a chemotherapy medicine?
No, Axitinib is a targeted therapy medicine not a chemotherapy drug. It is classified as a tyrosine kinase inhibitor (TKI), which attcks only specific VEGFR 1, 2, 3 receptors to eliminate tumors. Chemotherapy on the other hand, attacks both healthy and cancer cells indiscriminately.
How long do you take axitinib?
There is no prefixed duration for the treatment and it relies solely on the discretion of your oncologist. Some patients take axitinib for months, while other treatments can last for years. Only a licensed oncologist can recommend a treatment duration.
What is the price of axinix 5mg in Pakistan?
Axinix 5mg costs between 90,000 and 200,000 in Pakistan. At PakMeds, we offer the lowest prices because you deserve affordability. Order now with a valid prescription.
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