Axinix 5 mg Ingredients and Usage

The active ingredient is Axitinib, an oral kinase inhibitor. The 5 mg strength is often used as the standard starting dose, taken twice daily, approximately 12 hours apart.

Axinix is clinically indicated for the treatment of:

• Advanced Renal Cell Carcinoma (RCC): Used as a second-line therapy in patients who have failed one prior systemic therapy for metastatic disease.
• Adjuvant Therapy: May be used in combination with other agents for advanced RCC.

How Does Axinix Work?

Axitinib is a targeted molecular therapy that primarily works by blocking the signals that promote blood vessel formation (angiogenesis) and tumor growth. Its mechanism is focused on key receptor tyrosine kinases (RTKs):

1. VEGFR Inhibition: Axitinib potently and selectively inhibits the activity of Vascular Endothelial Growth Factor Receptors (VEGFR-1, -2, and -3). These receptors are frequently over-expressed in kidney cancer cells and the associated blood vessel lining cells.
2. Angiogenesis Blockade: By blocking VEGFR signaling, Axitinib inhibits the downstream effects that lead to the formation of new blood vessels that supply the tumor. This starves the cancer cells of essential nutrients and oxygen.
3. Tumor Growth Inhibition: The drug’s action leads to reduced tumor cell proliferation and survival, thereby delaying disease progression in advanced RCC.

Axinix 5 mg Side Effects and Warnings

Axitinib is a powerful drug that requires careful monitoring, particularly of blood pressure and thyroid function. Common side effects often include:

• Hypertension (High Blood Pressure): Very common and often requires aggressive management with anti-hypertensive drugs.
• Diarrhea
• Fatigue and Asthenia
• Dysphonia (Voice changes/Hoarseness)
• Palmar-plantar erythrodysesthesia syndrome (PPE, Hand-Foot Syndrome)

Serious Warnings and Critical Precautions:

1. Hypertension and Hypertensive Crisis: Severe hypertension, sometimes resulting in hypertensive crisis, is a key risk. Blood pressure must be monitored frequently (starting before treatment and regularly throughout).
2. Thrombotic Events: Increased risk of developing arterial and venous thrombotic events, including heart attack, stroke, and pulmonary embolism.
3. Hemorrhage (Bleeding): Serious, sometimes fatal, bleeding events have been reported, including gastrointestinal hemorrhage. Axitinib can inhibit wound healing, similar to other anti-angiogenesis agents.
4. Thyroid Dysfunction: Hypothyroidism (underactive thyroid) is very common and requires monitoring and possible hormone replacement therapy.
5. Contraindication: Not recommended for use in patients with severe bleeding risk or uncontrolled hypertension.

Axinix 5 mg Storage Conditions

Axinix Tablets should be stored under standard conditions to maintain stability:

• Store the tablets at controlled room temperature, typically between 20°C and 25°C (68°F and 77°F).
• Keep the tablets in the original blister pack or container to protect them from moisture.
• Administration: Tablets should be taken whole with a glass of water, with or without food. Doses must be taken approximately 12 hours apart.
• Keep out of the reach of children.