Brolizum (Pembrolizumab) 100mg/4ml
Brolizum 100mg/4ml Injection contains Pembrolizumab, an immunotherapy medicine used under expert oncological supervision to treat various advanced and metastatic cancers.
Imported medicine — supplied under DRAP NOC. Arranged on demand through the No Objection Certificate process of the Drug Regulatory Authority of Pakistan, only for patients with a valid prescription who complete identity verification. Non-returnable once dispensed. Learn more about NOC orders →
Overview
Brolizum 100mg/4ml contains Pembrolizumab, an advanced immunotherapy medicine designed to assist the immune system in targeting cancer cells. It is prescribed by oncologists for various advanced malignancies, including non-small cell lung cancer, melanoma, renal cell carcinoma, cervical cancer, and urothelial carcinoma. PakMeds provides access to authentic oncology medications with strict cold-chain handling across Pakistan.
Important Information
Prescription medicine: Brolizum is supplied only against a valid prescription from a registered doctor. Use it only as directed by your doctor.
NOC medicine: Brolizum is only available to patients willing to complete identity verification and the NOC (No Objection Certificate) process. It is arranged on demand against a valid prescription.
Cold-chain product: Brolizum must be kept refrigerated between 2°C and 8°C. PakMeds delivers it in temperature-controlled packaging. Refrigerate it as soon as it arrives and do not freeze it.
Key Benefits of Brolizum
Helps the body's natural immune system recognise and attack cancer cells
Prescribed for a broad range of advanced and metastatic solid tumours
Targeted immunotherapy mechanism distinct from standard chemotherapy
Formulated as a concentrated solution for precise intravenous infusion
Handled under strict cold-chain standards to ensure product integrity
Brolizum Ingredients and Usage
Brolizum contains Pembrolizumab, which belongs to a class of oncology medicines known as programmed cell death receptor-1 (PD-1) blocking antibodies or immune checkpoint inhibitors. Unlike conventional chemotherapy that directly destroys rapidly dividing cells, Pembrolizumab enhances the immune system's ability to detect and combat tumour growth.
Oncologists prescribe Brolizum for the treatment of various advanced, recurrent, or metastatic cancers. These include advanced melanoma, non-small cell lung cancer, head and neck squamous cell carcinoma, classical Hodgkin lymphoma, renal cell carcinoma, urothelial carcinoma, cervical cancer, gastric cancer, and esophageal carcinoma.
Treatment eligibility often depends on specific diagnostic testing, such as evaluation of tumour PD-L1 expression or specific biomarker profiles. Your attending oncologist determines whether Brolizum is appropriate for your specific diagnosis and stage of disease.
How Does Brolizum Work?
Pembrolizumab operates by binding to the PD-1 receptor located on T cells, a type of white blood cell involved in immune defense. Many cancer cells produce proteins called PD-L1 and PD-L2, which engage the PD-1 receptor and effectively switch off the T cell's ability to attack the tumour.
By selectively blocking the interaction between PD-1 and its ligands, Brolizum removes this inhibitory signal. This restores and reactivates the T cells, enabling them to recognise, infiltrate, and destroy the cancer cells throughout the body.
How to Use Brolizum
Brolizum is supplied as a concentrated solution in a single-dose vial and must be diluted by a trained healthcare professional prior to administration.
It is administered strictly as an intravenous (IV) infusion in a clinical setting, such as a hospital or specialized day-care oncology clinic, under the direct supervision of an oncologist.
Your healthcare team determines the exact dose and infusion schedule based on your clinical condition and treatment plan. Regular monitoring and adherence to prescribed clinical visits are essential for safe administration.
Brolizum Side Effects
Because Brolizum stimulates the immune system, it can cause inflammation in normal tissues and organs. Patients should immediately inform their oncology team if they experience any new, persistent, or worsening symptoms.
Fatigue and general weakness
Musculoskeletal pain and joint aches
Decreased appetite
Nausea and mild diarrhea
Cough and shortness of breath
Skin rash and itching
Fever and chills
Changes in thyroid function levels
Warnings
Can cause severe or life-threatening immune-mediated adverse reactions affecting the lungs, colon, liver, kidneys, skin, or endocrine glands.
Infusion-related reactions, including hypersensitivity and anaphylaxis, may occur during or shortly after administration.
Immune-mediated pneumonitis (lung inflammation) requires immediate medical evaluation and management with corticosteroids if confirmed.
Endocrine disorders such as hypo- or hyperthyroidism, adrenal insufficiency, and type 1 diabetes mellitus can develop during treatment.
May cause fetal harm when administered to a pregnant woman.
Precautions and Who Should Avoid It
Tell your doctor if you have a history of autoimmune diseases such as lupus, Crohn's disease, or rheumatoid arthritis.
Inform your healthcare team if you have previously experienced severe skin reactions or organ transplant procedures.
Women of childbearing potential must use effective contraception during treatment and for a specified period after the final dose.
Breastfeeding should be discontinued during treatment with Brolizum as advised by your physician.
Ensure your doctor is aware of any pre-existing liver, kidney, or pulmonary conditions before starting therapy.
Drug and Food Interactions
Systemic corticosteroids or immunosuppressants used prior to starting Brolizum may interfere with its therapeutic effectiveness, though they may be required to treat side effects.
Inform your oncologist about all prescription medicines, over-the-counter drugs, vitamins, and herbal supplements you are currently taking.
Live vaccines should generally be avoided during immunotherapy treatment due to potential risks to the immune system.
Brolizum Storage Conditions
Brolizum must be kept refrigerated between 2°C and 8°C in its original pack to protect it from light. Do not freeze or shake the vial. Keep this and all medicines out of the reach of children.
Frequently Asked Questions
What is Brolizum used for?
Brolizum contains Pembrolizumab and is used under expert oncological supervision to treat several types of advanced and metastatic cancers, including lung cancer, melanoma, kidney cancer, and cervical cancer.
How is Brolizum administered?
Brolizum is administered as an intravenous (IV) infusion by a qualified healthcare professional in a hospital or specialized oncology center. It is not an oral medication.
How does PakMeds handle temperature-sensitive medicines like Brolizum?
PakMeds maintains strict cold-chain protocols for medicines requiring refrigeration. Cold-chain items are stored between 2°C and 8°C and dispatched using specialized temperature-controlled packaging across supported regions in Pakistan.
Is a prescription required to order Brolizum from PakMeds?
Yes, Brolizum is a prescription-only oncology treatment. PakMeds requires a valid prescription and verification from your attending oncologist before fulfilling your order.
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