Regonix 40mg Tabs. 28`s

Doctors prescribe it after other targeted therapies or chemotherapy regimens stop working.

Regonix 40mg Tablets Ingredients and Usage

Regonix 40mg Tablets contain regorafenib, an oral multi kinase inhibitor belonging to the targeted anticancer drug class. Doctors prescribe it for metastatic colorectal cancer that has progressed after fluoropyrimidine, anti VEGF, and anti EGFR based treatment.

Oncologists also use Regonix 40mg Tablets for gastrointestinal stromal tumors resistant to imatinib and sunitinib, and for hepatocellular carcinoma in patients previously treated with sorafenib. Treatment follows a cycle of daily dosing for 21 days, followed by a 7 day break.

How Does Regonix 40mg Tablets Work?

Regorafenib inhibits multiple membrane bound and intracellular kinases, including VEGFR1, VEGFR2, VEGFR3, KIT, PDGFR, FGFR, and BRAF. These kinases drive tumor angiogenesis, the formation of new blood vessels that feed cancer growth.

By blocking this network of signaling pathways, Regonix 40mg Tablets limit blood supply to tumors and slow the proliferation of cancer cells. The drug also interferes with the tumor microenvironment, restricting the conditions cancer cells need to survive and spread.

Regonix 40mg Tablets Side Effects

Regonix 40mg Tablets commonly cause skin, digestive, and general side effects. Hand foot skin reaction affects a large proportion of patients and often needs dose adjustment.

• Hand foot skin reaction with redness, swelling, or peeling on palms and soles

• Fatigue

• Diarrhea

• Decreased appetite and weight loss

• High blood pressure

• Voice changes or hoarseness

• Mouth sores

Warnings

• Regonix 40mg Tablets carry a boxed warning for severe and sometimes fatal hepatotoxicity; monitor liver function before starting and throughout treatment.

• The medicine increases the risk of severe bleeding, which can be life threatening; avoid use in patients with recent significant hemorrhage.

• Regonix 40mg Tablets can cause gastrointestinal perforation or fistula formation, particularly in patients with abdominal cancers.

• Monitor blood pressure regularly, since hypertension is common and may require dose adjustment or antihypertensive therapy.

• Stop treatment and seek immediate care for signs of severe skin reactions, including Stevens Johnson syndrome or toxic epidermal necrolysis.

• Avoid Regonix 40mg Tablets in pregnancy; men and women should use effective contraception during treatment and for two months after the last dose.

• Wound healing complications can occur, so treatment should be interrupted before and after major surgery.

Regonix 40mg Tablets Storage Conditions

Store Regonix 40mg Tablets at room temperature below 30°C, away from direct sunlight and moisture. Keep tablets in their original blister packaging until the dose is due, and avoid refrigeration. Store this medicine out of reach of children, since accidental ingestion of an anticancer drug can cause serious harm.