Ketorite Tablets deliver essential amino acid nutrition therapy for patients with chronic kidney disease (CKD). Each tablet supplies alpha keto analogues that reduce uraemic toxins, protect residual kidney function, and prevent malnutrition. Buy Ketorite Tablets online at PakMeds and save on genuine, prescription verified medicine delivered to your door.

Ketorite Tablets Ingredients and Usage

Ketorite Tablets contain ten active components: five alpha keto acid calcium salts and five essential amino acids. The keto acid salts are alpha ketophenylalanine (68mg), alpha ketoisoleucine (67mg), alpha ketoleucine (101mg), alpha ketovaline (86mg), and alpha hydroxymethionine (59mg). The essential amino acids are L-Lysine acetate (105mg), L-Threonine (53mg), L-Histidine (38mg), L-Tryptophan (23mg), and L-Tyrosine (30mg).

Ketorite Tablets are indicated for adults with chronic kidney disease (CKD) whose glomerular filtration rate (GFR) is below 25 mL/min. Treatment requires a concurrent dietary protein restriction of 40 grams per day or less. The tablets are used as long as GFR remains below this threshold and protein intake stays restricted.

How Does Ketorite Tablets Work?

Ketorite Tablets work through transamination — a metabolic process that converts keto and hydroxy analogues into essential amino acids. This conversion draws nitrogen from non-essential amino acids already present in the body. By reusing this nitrogen, Ketorite reduces urea formation and lowers the accumulation of uraemic toxins in the blood.

The keto acid components do not trigger hyperfiltration in the remaining functional nephrons, protecting residual kidney tissue. They also improve renal hyperphosphataemia (elevated phosphate) and counteract secondary hyperparathyroidism — both common in advanced CKD. Combined with a very low protein diet, Ketorite reduces bone disease risk by addressing renal osteodystrophy.

Ketorite Tablets Side Effects

Ketorite Tablets have a very favorable tolerability profile. The CCL official leaflet classifies only one adverse reaction, though mild gastrointestinal effects are possible in some patients:

• Hypercalcaemia (very rare per CCL leaflet) — elevated blood calcium; reduce vitamin D intake if this occurs and lower calcium intake if it persists
• Nausea or vomiting — mild gastrointestinal effects possible, particularly during early treatment
• Abdominal discomfort, bloating, or flatulence — digestive adjustment during initial use
• Allergic reaction — skin rash, itching, or swelling; seek immediate care if breathing difficulty develops

Warnings

• Hypercalcaemia contraindication: Do not use Ketorite in patients with existing elevated blood calcium. Each tablet contains 50mg calcium — cumulative calcium intake must be monitored throughout treatment.
• Disturbed amino acid metabolism contraindication: Ketorite is contraindicated in patients with impaired amino acid metabolism. Administration would place excess burden on the kidneys and worsen the condition.
• Calcium drug interactions: Tetracyclines, quinolones (ciprofloxacin, norfloxacin), iron supplements, fluoride, and estramustine form insoluble compounds with calcium. Take these at least 2 hours before or after Ketorite.
• Cardioactive glycosides: If Ketorite raises serum calcium, susceptibility to digoxin and other cardioactive glycosides increases. This elevates the risk of cardiac arrhythmia. Monitor closely in patients on these medicines.
• Aluminium hydroxide: As uraemic symptoms improve during Ketorite therapy, the aluminium hydroxide dose may need reduction. Monitor serum phosphate levels during concurrent use.
• Phenylketonuria (PKU): Ketorite contains phenylalanine (as alpha ketophenylalanine). Patients with hereditary phenylketonuria must factor this into their daily phenylalanine calculations.
• Serum calcium monitoring: Monitor serum calcium levels regularly throughout the entire treatment course. Adjust dose or calcium sources if hypercalcaemia develops.
• Pregnancy and breastfeeding: No adequate safety data exist for use during pregnancy. Animal studies show no direct harm, but caution is advised. Safety during lactation is also not established — consult your doctor before use.
• Paediatric use: No clinical experience exists with Ketorite in children. Use in paediatric patients is not currently recommended.

Ketorite Tablets Storage Conditions

• Store below 30°C — do not expose to high temperatures
• Protect from direct sunlight, heat, and moisture at all times
• Keep in the original packaging to prevent degradation
• Do not store in the bathroom — humidity affects tablet stability
• Keep out of reach of children at all times
• Dispose of expired tablets as directed by your pharmacist — do not flush or discard in household waste

Ketorite Tablets Price in Pakistan

Ketorite Tablets are available in Pakistan at approximately Rs. 5,529 per pack of 100 tablets. This price is consistent across major online pharmacies including Healthwire and D.Watson, though prices may vary slightly by outlet and availability.

Ketoanalogues are a specialist CKD nutritional therapy with limited generic competition in Pakistan. PakMeds stocks genuine CCL Pharmaceuticals Ketorite with fast, verified delivery nationwide — order Ketorite Tablets at PakMeds today and ensure uninterrupted therapy.

Ketorite Tablets — Frequently Asked Questions

Who should take Ketorite Tablets and when is it prescribed?

Ketorite Tablets are prescribed for adult CKD patients whose glomerular filtration rate (GFR) has fallen below 25 mL/min. GFR is a measure of how well the kidneys filter waste — a reading below 25 indicates stage 4 or 5 CKD. At this stage, protein metabolism is severely impaired and uraemic toxin levels rise significantly.

Ketorite is also used in diabetic nephropathy — kidney damage caused by long term diabetes — to slow further deterioration. The therapy must always run alongside a dietary protein restriction of 40g per day or less. Prescribing without the accompanying diet reduces its clinical benefit significantly.

How should Ketorite Tablets be taken?

The standard adult dose is 4 to 8 tablets, three times daily, taken during meals. Tablets must not be chewed or crushed — swallow them whole with water. Ingestion during meals is essential, as food promotes proper absorption and transamination into the corresponding amino acids.

The dose is based on a body weight of approximately 70kg — your nephrologist will adjust it based on your individual weight and clinical response. Do not stop taking Ketorite without medical advice, even if you feel well. Consistent use alongside dietary protein restriction is necessary for the therapy to protect kidney function.

Can Ketorite Tablets slow the progression of kidney disease?

Yes — clinical evidence supports the use of keto analogue supplementation in slowing CKD progression. A 2017 study published in PLOS ONE found that ketoanalogue supplementation decreased the risk of dialysis and mortality in patients with advanced CKD and anaemia. The mechanism involves reducing urea production and uraemic toxin buildup without overloading the kidneys with nitrogen.

Ketorite also addresses secondary complications of CKD including hyperphosphataemia, hyperparathyroidism, and renal osteodystrophy. These complications accelerate kidney damage and increase cardiovascular risk if left unmanaged. Regular monitoring of GFR, serum calcium, and phosphate levels ensures the therapy remains effective over time.