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Heparin Vaxcel Injection 5ml
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Overview
| Manufacturer | Various Pharmaceutical Companies |
| Active Ingredients | Heparin Sodium |
| Medicine Strength | Various strengths (5000 IU/ml commonly available) |
| Formulation | Solution in Pre-filled Syringe for Subcutaneous Injection |
| Requires Prescription? | Yes (Hospital/Clinic Use - Physician prescription required) |
| Generics | Heparin |
Heparin Sodium Ingredients and Usage
The active ingredient is Heparin Sodium, a highly sulfated glycosaminoglycan anticoagulant. The pre-filled syringe is administered by subcutaneous injection, typically in the abdominal fat layer, with dosage determined by the specific clinical indication and patient weight.
Heparin Sodium is clinically indicated for:
- Prophylaxis of deep vein thrombosis (DVT) and pulmonary embolism (PE)
- Treatment of established venous thromboembolism
- Prevention of clotting during surgical procedures
- Maintenance of catheter and intravenous line patency
- Treatment of unstable angina and myocardial infarction
How Does Heparin Sodium Work?
Heparin Sodium provides anticoagulant effects through antithrombin III activation:
- Antithrombin III Activation: Binds to antithrombin III, accelerating its inhibitory activity
- Coagulation Factor Inhibition: Inactivates thrombin (Factor IIa) and Factor Xa
- Rapid Onset: Provides immediate anticoagulant effect after administration
- Short Duration: Effects are reversible with protamine sulfate
Heparin Sodium Side Effects and Warnings
Common side effects include bleeding, heparin-induced thrombocytopenia, injection site reactions, and elevated liver enzymes. Most serious adverse effects are related to bleeding complications.
Serious Considerations
- Heparin-Induced Thrombocytopenia: May cause HIT - monitor platelet counts regularly
- Bleeding Risk: Significant risk of major bleeding - monitor coagulation parameters
- Spinal Procedures: Increased risk of spinal hematoma with neuraxial anesthesia
- Osteoporosis: Long-term use may cause bone density reduction
- Allergic Reactions: May cause hypersensitivity reactions including anaphylaxis
Heparin Sodium Storage Conditions
Heparin Sodium Pre-filled Syringes require proper storage conditions:
- Store below 25°C protected from light
- Keep in original packaging until use
- Protect from freezing
- Use immediately after removing from packaging
- Do not use if discolored or contains particles
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