Epival CR 500mg Tablets (5x10s) is a high-quality pharmaceutical product used for sustained-release control of seizures and mood stabilization in bipolar disorder, available for home delivery at PakMeds.

Epival CR 500mg Tablets Ingredients and Usage

Epival CR (Controlled Release) 500mg Tablets are an advanced formulation containing a combination of Sodium Valproate and Valproic Acid. This version is designed to release the medication slowly into the system over a 24-hour period. It is used in Pakistan to treat various types of epilepsy and to stabilize mood in patients with bipolar disorder.

The CR formulation is particularly beneficial because it allows for once or twice daily dosing while maintaining very stable blood levels. This reduces the “peaks and troughs” associated with standard tablets, leading to better seizure control and fewer side effects. PakMeds provides Epival CR 500mg to support patients who require a steady, long-acting therapeutic effect for their neurological health.

It is also used for migraine prophylaxis in patients who do not respond well to other treatments. The controlled-release nature makes it a convenient option for long-term maintenance, ensuring that the medication is working consistently throughout the day and night.

How Does Epival CR 500mg Tablets Work?

Epival CR works by increasing the concentration of GABA in the brain. By inhibiting the enzymes that break down GABA and promoting its synthesis, the medication ensures that the brain has a higher level of this natural “calming” chemical. This raises the seizure threshold and prevents the over-activity of the brain’s electrical circuits.

The unique controlled-release matrix of the tablet ensures that the active valproate is released at a constant rate as it passes through the digestive tract. This provides a smoother plasma concentration profile. By avoiding high peak levels in the blood, the medication is often better tolerated by the stomach and reduces the intensity of side effects like tremors or sedation.

This steady-state delivery is crucial for maintaining the delicate balance required to prevent seizures while keeping the patient’s mood stable. It helps in smoothing out the rapid cycling sometimes seen in bipolar patients.

Epival CR 500mg Tablets Side Effects

Common side effects of the CR formulation include mild gastric irritation, dizziness, and changes in appetite. Some patients may experience a slight increase in weight or temporary thinning of hair. Because the medication is released slowly, some of the acute side effects associated with immediate-release tablets are often reduced.

Serious side effects such as liver dysfunction or blood disorders (low platelet count) are rare but require regular medical monitoring. If you notice unusual bruising, persistent fatigue, or dark-colored urine, contact your doctor immediately. PakMeds recommends regular follow-ups to ensure the medication is being managed safely and effectively.

List of Warnings:

• Tablets must be swallowed whole; do not crush or chew them as it destroys the controlled-release mechanism.
• Avoid use in pregnancy due to the high risk of physical and developmental defects in the baby.
• Use with caution if you have significant liver disease or a history of pancreatitis.
• Alcohol should be avoided as it can increase the sedative effects of the medication.
• Inform your doctor if you are taking other antiepileptics, as interactions are common.

Epival CR 500mg Tablets Storage Conditions

Store in a dry place at room temperature below 30°C. Keep the tablets in their original packaging to protect them from moisture. Ensure the medicine is stored in a secure location away from the reach of children.