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Efacurim 50mg/5ml Injection
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Overview
| Manufacturer | Getz Pharma Pakistan |
| Active Ingredients | Fluconazole |
| Medicine Strength | 50mg per 5mL (10mg/mL) |
| Formulation | Solution for Intravenous Infusion |
| Requires Prescription? | Yes (Hospital/Specialist use only) |
| Generics | Fluconazole |
Efacurim Ingredients and Usage
The active ingredient is Fluconazole, a bis-triazole antifungal agent. The 50mg/5mL solution is administered as intravenous infusion over approximately 30-60 minutes.
Efacurim is clinically indicated for:
- Systemic candidiasis and cryptococcal meningitis
- Esophageal and oropharyngeal candidiasis
- Prophylaxis in immunocompromised patients
- Urinary tract and peritoneal fungal infections
How Does Efacurim Work?
Efacurim exerts antifungal activity through ergosterol synthesis inhibition:
- Lanosterol Demethylase Inhibition: Blocks cytochrome P450 14α-demethylase
- Ergosterol Depletion: Reduces essential fungal cell membrane component
- Membrane Integrity Disruption: Causes increased permeability and cell death
- Fungistatic Action: Inhibits fungal growth and replication
Efacurim Side Effects and Warnings
Common side effects include headache, nausea, abdominal pain, and skin rash. Most reactions are mild and self-limiting.
Serious Considerations
- Hepatic Toxicity: Monitor liver function during prolonged therapy
- QT Prolongation: May cause cardiac arrhythmias in susceptible patients
- Drug Interactions: Multiple interactions with CYP450 metabolized drugs
- Renal Impairment: Dose adjustment required in kidney dysfunction
- Pregnancy Risk: Category D - avoid in first trimester
Efacurim Storage Conditions
Efacurim Injection requires proper storage handling:
- Store at room temperature below 25°C
- Protect from light and freezing
- Use opened vials immediately
- Discard if solution appears discolored or contains particles
- Keep out of reach of children
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