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Ecavir 0.5mg Tablet 30s
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Overview
| Manufacturer | Getz Pharma Pakistan |
| Active Ingredients | Entecavir |
| Medicine Strength | 0.5mg per Tablet |
| Formulation | Film-Coated Tablets |
| Requires Prescription? | Yes (Gastroenterologist/Hepatologist prescription) |
| Generics | Entecavir |
Ecavir Ingredients and Usage
The active ingredient is Entecavir, a guanosine nucleoside analogue. The 0.5mg tablet is taken once daily on an empty stomach at least 2 hours before or after food.
Ecavir is clinically indicated for:
- Chronic hepatitis B virus infection in adults
- HBV replication-active liver disease
- Treatment-naïve patients with compensated liver disease
- Patients with elevated HBV DNA and ALT levels
How Does Ecavir Work?
Ecavir provides potent antiviral activity through selective HBV polymerase inhibition:
- HBV Polymerase Inhibition: Competitively inhibits HBV reverse transcriptase
- DNA Chain Termination: Incorporates into viral DNA causing chain termination
- Viral Suppression: Reduces HBV DNA to undetectable levels
- High Genetic Barrier: Low rate of resistance development
Ecavir Side Effects and Warnings
Common side effects include headache, fatigue, dizziness, and nausea. Most reactions are mild and transient.
Serious Considerations
- Lactic Acidosis: Risk of severe lactic acidosis with hepatic steatosis
- Hepatitis Exacerbation: Acute severe exacerbation upon discontinuation
- Renal Impairment: Dose adjustment required in kidney dysfunction
- HIV Coinfection: May select for HIV resistance if undiagnosed
- Treatment Duration: Long-term therapy usually required
Ecavir Storage Conditions
Ecavir Tablets require proper storage conditions:
- Store at room temperature below 30°C
- Keep in original packaging protected from moisture
- Protect from light and excessive heat
- Keep out of reach of children
- Do not use after expiration date
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