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Depo-Pred Injection 40mg/ml 1's

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Overview

ManufacturerPfizer Pakistan
Active IngredientsMethylprednisolone Acetate
Medicine Strength40mg per 2mL (20mg/mL)
FormulationSuspension for Intramuscular/Intra-articular Injection
Requires Prescription?Yes
GenericsMethylprednisolone Acetate

Depo-Pred Ingredients and Usage

The active ingredient is Methylprednisolone Acetate, a synthetic glucocorticoid in repository form. The suspension is administered as deep intramuscular or intra-articular injection.Depo-Pred is clinically indicated for:
  • Rheumatoid arthritis and osteoarthritis

  • Allergic conditions and dermatological diseases

  • Collagen vascular diseases and systemic lupus

  • Intra-articular inflammation and bursitis

How Does Depo-Pred Work?

Depo-Pred provides sustained anti-inflammatory effects through multiple mechanisms:
  1. Gene Expression Modulation: Alters transcription of inflammatory proteins

  2. Phospholipase Inhibition: Reduces prostaglandin and leukotriene production

  3. Immune Cell Suppression: Decreases lymphocyte and macrophage activity

  4. Prolonged Release: Acetate ester provides sustained drug release

Depo-Pred Side Effects and Warnings

Common side effects include hyperglycemia, fluid retention, mood changes, and injection site reactions. Most effects are dose and duration dependent.

Serious Considerations

  1. Adrenal Suppression: Prolonged effect requires gradual withdrawal

  2. Infection Risk: Masks signs of infection and increases susceptibility

  3. Osteoporosis: Long-term use may cause significant bone loss

  4. Hyperglycemia: May precipitate or worsen diabetes mellitus

  5. Joint Damage: Repeated intra-articular injections may damage cartilage

Depo-Pred Storage Conditions

Depo-Pred Injection requires proper storage conditions:
  • Store at room temperature below 25°C

  • Protect from light and freezing

  • Shake well before use to resuspend particles

  • Do not use if clumping or excessive settling occurs

  • Keep out of reach of children

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