Darbazine Injection 200 mg
Darbazine 200mg Injection contains dacarbazine, an alkylating chemotherapy agent used as part of the ABVD regimen for Hodgkin lymphoma and for advanced malignant melanoma. Buy Darbazine 200mg Injection at PakMeds with a valid prescription for genuine Pharmedic Laboratories stock.
Overview
A qualified oncology team administers it as an intravenous infusion after antiemetic premedication.
Manufacturer | Pharmedic Laboratories (Pvt) Ltd |
|---|---|
Active Ingredient(s) | Dacarbazine |
Strength | 200mg |
Pack Size | 1 vial |
Prescription Required | Yes |
Generic Name(s) | Dacarbazine, DTIC |
Darbazine 200mg Injection Ingredients and Usage
Darbazine 200mg Injection contains dacarbazine, an alkylating agent belonging to the imidazole carboxamide anticancer drug class. Oncologists prescribe it as standard therapy for Hodgkin lymphoma, given as part of the ABVD combination protocol.
Darbazine 200mg Injection also treats advanced malignant melanoma and soft tissue sarcomas, and is used in pediatric oncology for neuroblastoma. A specialist experienced in chemotherapy administration must supervise treatment throughout.
How Does Darbazine 200mg Injection Work?
Dacarbazine is metabolized in the liver into an active alkylating compound that attaches to DNA within cancer cells. This compound forms crosslinks and adducts that damage the DNA structure and prevent normal replication.
By inhibiting DNA replication, Darbazine 200mg Injection stops cancer cells from dividing and triggers cell death. This alkylating action underlies its effectiveness in Hodgkin lymphoma and melanoma, both of which respond to DNA damaging chemotherapy.
Darbazine 200mg Injection Side Effects
Darbazine 200mg Injection commonly causes severe nausea and vomiting, affecting over 90 percent of patients without adequate premedication.
Severe nausea and vomiting
Low white blood cell and platelet counts
Loss of appetite and metallic taste
Flu-like symptoms, including fever and muscle aches, appearing 7 to 10 days after treatment
Hair loss
Pain or burning along the injection site
Facial flushing
Warnings
Darbazine 200mg Injection can cause hepatic veno-occlusive disease, a rare but often fatal liver condition; it typically develops during the second treatment cycle with fever, abdominal pain, and jaundice.
Liver function tests must be checked before each treatment cycle, and treatment should be stopped if signs of liver injury appear.
Bone marrow suppression is a dose limiting toxicity; complete blood counts must be monitored closely, with the lowest blood counts typically occurring 21 to 25 days after treatment.
Darbazine 200mg Injection is a vesicant; extravasation during infusion can cause severe pain, tissue damage, and necrosis, so administration requires extreme care.
The medicine causes marked photosensitivity; patients should use high-SPF sunscreen and protective clothing, since even brief sun exposure can cause a severe burn.
Severe hypersensitivity reactions, including rare anaphylaxis, have been reported during infusion.
Darbazine 200mg Injection carries a high risk of permanent infertility in both men and women; discuss fertility preservation options with a specialist before starting treatment, and use effective contraception, since it can cause fetal harm.
Darbazine 200mg Injection Storage Conditions
Store Darbazine 200mg Injection protected from light, following the storage instructions on the vial label. Keep the vial in its original packaging until immediately before use. Store this medicine out of reach of children and ensure only trained healthcare staff handle preparation and administration.
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