D Blastin Injection 20mg

Manufacturer	Pharmevo Pakistan
Active Ingredients	Daunorubicin Hydrochloride
Medicine Strength	20mg per vial
Formulation	Powder for Solution for Intravenous Injection
Requires Prescription?	Yes (Oncologist prescription required)
Generics	Daunorubicin

D Blastin Ingredients and Usage

The active ingredient is Daunorubicin Hydrochloride, an anthracycline antibiotic. The 20mg powder requires reconstitution before slow intravenous push or infusion. D Blastin is clinically indicated for:

• Acute myeloid leukemia (AML) induction therapy
• Acute lymphoblastic leukemia (ALL) treatment
• Combination chemotherapy regimens
• Remission induction in leukemias

How Does D Blastin Work?

D Blastin exerts cytotoxic effects through multiple DNA damage mechanisms:

1. DNA Intercalation: Inserts between DNA base pairs disrupting structure
2. Topoisomerase II Inhibition: Prevents DNA repair and replication
3. Free Radical Generation: Produces reactive oxygen species causing cell damage
4. Apoptosis Induction: Triggers programmed cell death in leukemia cells

D Blastin Side Effects and Warnings

Common side effects include bone marrow suppression, nausea, vomiting, hair loss, and mucositis. Most effects require intensive supportive care.

Serious Considerations

1. Cardiotoxicity: Cumulative dose-dependent myocardial damage
2. Myelosuppression: Severe neutropenia and thrombocytopenia risk
3. Extravasation Injury: Causes severe tissue necrosis if leakage occurs
4. Secondary Leukemia: Increased risk of treatment-related AML
5. Renal/Hepatic Impairment: Requires dose adjustment in organ dysfunction

D Blastin Storage Conditions

D Blastin Injection requires careful storage handling:

• Store refrigerated between 2°C and 8°C
• Protect from light and freezing
• Use reconstituted solution within 24 hours
• Discard if solution appears discolored
• Follow cytotoxic drug safety protocols