Cytotrexate 2.5mg Tab. 100`s

Manufacturer	Howards
Active Ingredients	Methotrexate
Medicine Strength	2.5mg per Tablet
Formulation	Film-Coated Tablets
Requires Prescription?	Yes (Oncologist/Rheumatologist prescription required)
Generics	Methotrexate

Cytotrexate Ingredients and Usage

The active ingredient is Methotrexate, a folic acid analogue antimetabolite. The 2.5mg tablets are typically taken once weekly for autoimmune conditions. Cytotrexate is clinically indicated for:

• Rheumatoid arthritis and psoriasis
• Acute lymphoblastic leukemia
• Choriocarcinoma and trophoblastic tumors
• Autoimmune conditions like lupus and vasculitis

How Does Cytotrexate Work?

Cytotrexate provides cytotoxic and immunosuppressive effects through folate metabolism inhibition:

1. Dihydrofolate Reductase Inhibition: Blocks folic acid conversion to active form
2. DNA Synthesis Prevention: Inhibits purine and pyrimidine synthesis
3. Cell Division Arrest: Affects rapidly dividing cells
4. Anti-inflammatory Action: Reduces inflammatory cytokine production

Cytotrexate Side Effects and Warnings

Common side effects include mouth ulcers, nausea, liver enzyme elevation, and bone marrow suppression. Most effects are dose-dependent.

Serious Considerations

1. Hepatotoxicity: Regular liver function monitoring required
2. Myelosuppression: Weekly blood count monitoring essential
3. Pulmonary Toxicity: May cause interstitial pneumonitis
4. Renal Impairment: Dose adjustment needed in kidney dysfunction
5. Folate Supplementation: Folic acid reduces side effects without reducing efficacy

Cytotrexate Storage Conditions

Cytotrexate Tablets require proper storage conditions:

• Store at room temperature below 25°C
• Keep in original packaging protected from moisture
• Protect from light and excessive heat
• Keep out of reach of children
• Do not use after expiration date