Overview
| Manufacturer | Atco Laboratories Pakistan |
| Active Ingredients | Colistimethate Sodium |
| Medicine Strength | 1 Million International Units per vial |
| Formulation | Powder for Solution for Intravenous/Inhalation Use |
| Requires Prescription? | Yes (Hospital/Critical Care use only) |
| Generics | Colistimethate Sodium |
Colimate Ingredients and Usage
The active ingredient is Colistimethate Sodium, a polymyxin E antibiotic. The 1 MIU powder requires reconstitution for intravenous infusion or nebulizer administration.
Colimate is clinically indicated for:
Multidrug-resistant Pseudomonas aeruginosa infections
Carbapenem-resistant Enterobacteriaceae infections
Ventilator-associated pneumonia treatment
Cystic fibrosis pulmonary exacerbations
How Does Colimate Work?
Colimate provides bactericidal action through membrane disruption:
Membrane Permeabilization: Binds to bacterial outer membrane lipopolysaccharides
Cellular Content Leakage: Causes osmotic imbalance and cell death
Rapid Bacterial Killing: Exhibits concentration-dependent killing
Biofilm Penetration: Effective against biofilm-forming bacteria
Colimate Side Effects and Warnings
Common side effects include nephrotoxicity, neurotoxicity, and bronchospasm during inhalation. Most effects are dose-dependent and reversible.
Serious Considerations
Nephrotoxicity: Requires frequent renal function monitoring
Neuromuscular Blockade: May cause respiratory muscle weakness
Dosing Calculation: Based on ideal body weight and renal function
Drug Interactions: Enhanced toxicity with aminoglycosides
Loading Dose: Essential for achieving therapeutic levels quickly
Colimate Storage Conditions
Colimate Injection requires proper storage handling:
Store below 25°C protected from light
Use reconstituted solution within 24 hours if refrigerated
Protect from moisture and freezing
Discard if solution appears discolored or contains particles
Follow strict aseptic preparation techniques
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