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Clozaril 100mg Tabs. 50`s
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Overview
| Manufacturer | Novartis Pharma Pakistan |
| Active Ingredients | Clozapine |
| Medicine Strength | 100mg per Tablet |
| Formulation | Film-Coated Tablets |
| Requires Prescription? | Yes (Psychiatrist prescription required) |
| Generics | Clozapine |
Clozaril Ingredients and Usage
The active ingredient is Clozapine, a dibenzodiazepine derivative atypical antipsychotic. The 100mg tablet is taken once or twice daily with gradual dose titration.
Clozaril is clinically indicated for:
- Treatment-resistant schizophrenia
- Reducing suicidal behavior in schizophrenia patients
- Patients unresponsive to conventional antipsychotics
How Does Clozaril Work?
Clozaril provides antipsychotic effects through multiple receptor actions:
- Dopamine D4 Receptor Blockade: Selective antagonism with minimal D2 effects
- Serotonin 5-HT2A Antagonism: Improves negative symptoms and cognitive function
- Muscarinic and Histaminic Blockade: Contributes to side effect profile
- Adrenergic Receptor Effects: Causes orthostatic hypotension and sedation
Clozaril Side Effects and Warnings
Common side effects include sedation, hypersalivation, weight gain, and constipation. Most effects are manageable with dose adjustment.
Serious Considerations
- Agranulocytosis: Requires mandatory weekly blood monitoring for first 6 months
- Seizure Risk: Dose-dependent increased incidence of seizures
- Myocarditis: Potentially fatal cardiac inflammation, especially in first month
- Metabolic Syndrome: Weight gain, diabetes, and dyslipidemia monitoring needed
- Abrupt Discontinuation: Must be tapered gradually to avoid withdrawal symptoms
Clozaril Storage Conditions
Clozaril Tablets require proper storage conditions:
- Store at room temperature below 30°C
- Keep in original packaging protected from moisture
- Protect from light and excessive heat
- Keep out of reach of children
- Do not use after expiration date
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