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Clotles SS 60mg Injection
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Overview
| Manufacturer | Samarth Life Sciences Pakistan |
| Active Ingredients | Streptokinase |
| Medicine Strength | 60mg per vial (1.5 million IU) |
| Formulation | Powder for Solution for Intravenous Infusion |
| Requires Prescription? | Yes (Hospital/Emergency use only) |
| Generics | Streptokinase |
Clotless SS Ingredients and Usage
The active ingredient is Streptokinase, a bacterial protein that activates plasminogen. The 60mg powder requires reconstitution and administration as intravenous infusion over 30-60 minutes.
Clotless SS is clinically indicated for:
- Acute myocardial infarction within 12 hours of onset
- Massive pulmonary embolism with hemodynamic instability
- Deep vein thrombosis in selected cases
- Arterial thrombosis and embolism
How Does Clotless SS Work?
Clotless SS provides thrombolysis through plasminogen activation:
- Plasminogen Activation: Forms complex with plasminogen to create plasmin
- Fibrin Degradation: Plasmin breaks down fibrin clots into soluble fragments
- Clot Dissolution: Rapidly dissolves thrombi in coronary arteries
- Systemic Effect: Causes systemic fibrinogenolysis and anticoagulation
Clotless SS Side Effects and Warnings
Common side effects include bleeding complications, allergic reactions, hypotension, and arrhythmias. Most reactions require immediate medical attention.
Serious Considerations
- Bleeding Risk: Major hemorrhage including intracranial bleeding
- Hypersensitivity Reactions: Anaphylaxis and serum sickness possible
- Reperfusion Arrhythmias: Ventricular arrhythmias during coronary reperfusion
- Re-administration Risk: Neutralizing antibodies develop after first use
- Contraindications: Active bleeding, recent surgery, or stroke history
Clotless SS Storage Conditions
Clotless SS Injection requires strict storage protocols:
- Store refrigerated between 2°C and 8°C
- Protect from light and freezing
- Use reconstituted solution immediately
- Discard if solution appears discolored or contains particles
- Follow emergency drug handling guidelines
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