Cisplab Ingredients and Usage

The active ingredient is Cisplatin, a platinum-containing antineoplastic agent. The 50mg solution is administered as slow intravenous infusion with pre- and post-hydration.

Cisplab is clinically indicated for:

• Testicular, ovarian and bladder cancers
• Head and neck squamous cell carcinoma
• Small cell lung cancer
• Cervical cancer and esophageal carcinoma

How Does Cisplab Work?

Cisplab exerts its anticancer effects through DNA interaction:

1. DNA Cross-Linking: Forms covalent bonds with DNA purine bases
2. Cell Cycle Arrest: Primarily affects G2 phase progression
3. Apoptosis Induction: Triggers programmed cell death pathways
4. Replication Inhibition: Prevents DNA synthesis and cell division

Cisplab Side Effects and Warnings

Common side effects include severe nausea, vomiting, nephrotoxicity, and myelosuppression. Most effects require intensive supportive management.

Serious Considerations

1. Nephrotoxicity: Requires aggressive hydration and renal function monitoring
2. Ototoxicity: Cumulative hearing loss may be permanent
3. Neurotoxicity: Peripheral sensory neuropathy with repeated cycles
4. Bone Marrow Suppression: Regular CBC monitoring essential
5. Electrolyte Imbalance: Hypomagnesemia requires magnesium supplementation

Cisplab Storage Conditions

Cisplab Injection requires proper storage protocols:

• Store at room temperature below 30°C
• Protect from light and freezing
• Use diluted solution within 24 hours
• Discard if solution appears discolored or contains precipitate
• Follow cytotoxic drug safety guidelines