Cilapen Ingredients and Usage

The active ingredients are Imipenem and Cilastatin Sodium in 1:1 ratio. The powder requires reconstitution and administration as slow intravenous infusion over 20-60 minutes.

Cilapen is clinically indicated for:

• Severe intra-abdominal infections
• Complicated urinary tract infections
• Lower respiratory tract infections
• Septicemia and nosocomial pneumonia

How Does Cilapen Work?

Cilapen combines bactericidal activity with renal protection:

1. Cell Wall Synthesis Inhibition: Imipenem binds to penicillin-binding proteins
2. Broadest Spectrum: Covers Gram-positive, Gram-negative and anaerobic bacteria
3. Renal Protection: Cilastatin inhibits renal dehydropeptidase enzyme
4. Bacterial Killing: Causes rapid bactericidal action against pathogens

Cilapen Side Effects and Warnings

Common side effects include nausea, diarrhea, injection site reactions, and seizures at high doses. Most reactions are dose-related and reversible.

Serious Considerations

1. Seizure Risk: Higher incidence in renal impairment and CNS disorders
2. Cross-reactivity: Contraindicated in patients with penicillin allergy
3. Pseudomembranous Colitis: Risk of C. difficile-associated diarrhea
4. Renal Impairment: Dose adjustment required for creatinine clearance below 70mL/min
5. CNS Toxicity: May cause confusion, myoclonus and encephalopathy

Cilapen Storage Conditions

Cilapen IV Injection requires strict storage protocols:

• Store below 25°C protected from light
• Use reconstituted solution immediately or within 4 hours at room temperature
• Protect from freezing and excessive heat
• Discard if solution appears discolored or contains particles
• Follow aseptic preparation techniques