ManufacturerAtco Laboratories Limited
Active IngredientsPotassium Chloride with electrolytes and cardioprotective agents
Medicine StrengthVarious formulations (typically 20-30 mEq/L Potassium)
FormulationSterile Solution for Intracardiac Infusion
Requires Prescription?Yes (Cardiac Surgery use only)
GenericsCardioplegia Solution

Cardioplegia Ingredients and Usage

The solution contains Potassium Chloride as the primary arresting agent along with magnesium, calcium, buffers, and metabolic substrates. It is administered directly into the coronary arteries during cardiac surgery.

Cardioplegia is clinically indicated for:

  • Myocardial protection during coronary artery bypass surgery
  • Cardiac valve replacement and repair procedures
  • Congenital heart defect corrections
  • Aortic root and other complex cardiac surgeries

How Does Cardioplegia Work?

Cardioplegia induces controlled cardiac arrest through multiple protective mechanisms:

  1. Cardiac Arrest Induction: High potassium concentration depolarizes myocardial cells, stopping electrical activity
  2. Myocardial Protection: Reduces metabolic demand by 90% during arrest period
  3. Ischemic Protection: Contains substrates that maintain cellular integrity during ischemia
  4. Reperfusion Protection: Buffers and antioxidants minimize reperfusion injury

Cardioplegia Side Effects and Warnings

Potential complications include incomplete myocardial protection, electrolyte imbalances, and reperfusion injuries. Proper administration technique minimizes these risks.

Serious Considerations

  1. Hyperkalemia Risk: High potassium content requires careful monitoring to prevent systemic hyperkalemia
  2. Myocardial Stunning: Inadequate protection may lead to postoperative myocardial dysfunction
  3. Administration Technique: Requires precise coronary ostia cannulation by experienced cardiac surgeons
  4. Temperature Management: Both cold and warm cardioplegia techniques require strict temperature control
  5. Composition Variation: Different formulations (crystalloid, blood) require specific protocols

Cardioplegia Storage Conditions

Cardioplegia Injection requires specialized storage:

  • Store at controlled room temperature unless specified for cold storage
  • Protect from freezing and excessive heat
  • Use immediately after preparation or according to manufacturer guidelines
  • Inspect for clarity and absence of particles before use
  • Follow strict aseptic techniques during preparation
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