Acyclovir Injection 500mg (1×10ml) is a potent antiviral medication used for the treatment of serious herpes virus infections, including herpes simplex and varicella-zoster virus infections. It is commonly used in hospitalized patients and is available for purchase at PakMeds.

Acyclovir Injection Ingredients and Usage

Acyclovir Injection contains Acyclovir, a synthetic purine nucleoside analogue with potent antiviral activity against herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), and varicella-zoster virus (VZV).

It is primarily used for the treatment of severe or disseminated herpes infections, including herpes encephalitis, neonatal herpes, severe genital herpes, and herpes infections in immunocompromised patients.

In Pakistan, injectable acyclovir is commonly used in hospital settings where oral therapy is not suitable or when rapid antiviral action is required. PakMeds supplies Acyclovir Injection to support effective antiviral management in critical care and inpatient settings.

How Does Acyclovir Injection Work?

Acyclovir works by inhibiting viral DNA synthesis. After entering infected cells, acyclovir is converted into its active form, acyclovir triphosphate, by viral thymidine kinase and host cell enzymes.

This active metabolite selectively inhibits viral DNA polymerase and gets incorporated into the growing viral DNA chain, resulting in chain termination. This mechanism prevents viral replication without significantly affecting normal host cell DNA synthesis, making acyclovir highly selective for virus-infected cells.

Acyclovir Injection Side Effects

Common side effects of acyclovir injection include nausea, vomiting, diarrhea, headache, and localized inflammation at the injection site. More serious adverse effects may include renal impairment, particularly with rapid intravenous infusion or inadequate hydration, and neurological effects such as confusion, tremors, or hallucinations, especially in elderly patients or those with renal dysfunction.

PakMeds advises that kidney function and hydration status be closely monitored during therapy.

List of Warnings:

Use with caution in patients with renal impairment; dose adjustment is required. Ensure adequate hydration to prevent nephrotoxicity. Avoid rapid IV infusion. Not recommended for use without medical supervision. Monitor renal function during prolonged therapy.

Acyclovir Injection Storage Conditions

Store below 25°C in a dry place, protected from light. Reconstituted solutions should be used promptly or stored as per manufacturer’s instructions. Keep out of reach of children.