Acuron 3 mL Ingredients and Usage

Acuron contains Atracurium Besylate, a neuromuscular blocker supplied as a sterile solution
for IV administration. It is used for:

• General Anesthesia: To facilitate muscle relaxation during surgical procedures.
• Endotracheal Intubation: To provide deep muscle relaxation for airway tube insertion.
• Prolonged Muscle Relaxation: During long surgeries.
• Mechanical Ventilation Support: To reduce spontaneous muscle activity in ICU patients.

How Does Acuron Work?

Atracurium Besylate is a non-depolarizing neuromuscular blocking agent. It acts by:

1. Binding to acetylcholine receptors at the neuromuscular junction.
2. Blocking acetylcholine from activating skeletal muscle cells.
3. Causing reversible muscle paralysis required for surgery and intubation.
4. Undergoing organ-independent breakdown, mainly via Hofmann elimination and ester hydrolysis—making it safe in patients with renal or hepatic impairment.

Acuron 3 mL Side Effects and Warnings

Acuron must always be used with appropriate general anesthesia, as it causes paralysis but
does not induce unconsciousness or relieve pain. Monitoring with a nerve stimulator is
essential.

Common side effects (related to histamine release):

• Low blood pressure (hypotension)
• Increased heart rate (tachycardia)
• Skin flushing

Serious warnings:

Anaphylaxis: Severe allergic reactions may occur. Emergency treatment must be readily available.

Histamine Release: Use caution in patients with asthma or cardiovascular disease.

Neuromuscular Disorders: Conditions like Myasthenia Gravis greatly increase sensitivity—dose reduction is required.

Contraindication: Do not use in patients with known hypersensitivity to Atracurium Besylate.

Acuron 3 mL Storage Conditions

• Store refrigerated at 2°C–8°C (36°F–46°F).
• Do not freeze.
• Protect from light by keeping ampoules in original packaging.
• If stored at room temperature (up to 25°C), use within 14 days even if re-refrigerated.