Hilfovir Ingredients and Usage

The active ingredient is Tenofovir Disoproxil Fumarate, a nucleotide analog that inhibits viral replication. One 300mg tablet is taken once daily with food, as part of combination antiretroviral therapy for HIV or as monotherapy for Hepatitis B.

Hilfovir is clinically indicated for:

• Treatment of HIV-1 infection in combination with other antiretroviral agents
• Chronic Hepatitis B virus infection with compensated liver disease
• Pre-exposure prophylaxis (PrEP) for HIV prevention in high-risk individuals
• Post-exposure prophylaxis in combination with other antiretrovirals

How Does Hilfovir Work?

Hilfovir provides antiviral activity through nucleotide analog action:

1. Reverse Transcriptase Inhibition: Competes with natural substrate to inhibit viral DNA synthesis
2. Chain Termination: Incorporated into viral DNA causing premature chain termination
3. HIV Replication Suppression: Reduces HIV viral load in infected patients
4. HBV Replication Inhibition: Suppresses Hepatitis B virus replication

Hilfovir Side Effects and Warnings

Common side effects include nausea, diarrhea, headache, dizziness, rash, and mild to moderate renal impairment. Most adverse effects are manageable with continued treatment.

Serious Considerations

1. Renal Toxicity: May cause acute renal failure and Fanconi syndrome
2. Bone Mineral Density: Can cause decreases in bone mineral density
3. Lactic Acidosis: Risk of lactic acidosis and severe hepatomegaly with steatosis
4. Hepatitis B Flare: Discontinuation may cause acute exacerbation of Hepatitis B
5. Drug Interactions: Significant interactions with other nephrotoxic drugs

Hilfovir Storage Conditions

Hilfovir Tablets require proper storage conditions:

• Store below 30°C in original container
• Keep the bottle tightly closed
• Protect from moisture
• Keep out of reach of children
• Do not use after expiration date