Hilfo B Ingredients and Usage

The active ingredient is Tenofovir Alafenamide Fumarate, a phosphonate nucleotide prodrug that is more stable in plasma and efficiently delivers the active metabolite to hepatocytes. One 25mg tablet is taken once daily with food for optimal absorption and efficacy in Hepatitis B treatment.

Hilfo B is clinically indicated for:

• Chronic Hepatitis B virus infection in adults and adolescents
• Treatment of HBV with compensated liver disease
• Patients requiring long-term HBV suppression
• Individuals with renal impairment or bone density concerns

How Does Hilfo B Work?

Hilfo B provides potent antiviral activity through targeted delivery:

1. Enhanced Cellular Uptake: More efficiently taken up by hepatocytes than TDF
2. Intracellular Activation: Converted to active tenofovir diphosphate inside cells
3. HBV Polymerase Inhibition: Competes with natural substrate to inhibit viral DNA synthesis
4. Chain Termination: Incorporated into viral DNA causing premature chain termination

Hilfo B Side Effects and Warnings

Common side effects include headache, fatigue, cough, nausea, abdominal pain, and nasopharyngitis. Most adverse effects are mild and comparable to placebo.

Serious Considerations

1. HBV Flare Upon Discontinuation: Acute exacerbation of hepatitis may occur if discontinued
2. Drug Interactions: Potential interactions with drugs affecting renal function
3. Lactic Acidosis: Rare risk of lactic acidosis and severe hepatomegaly
4. Renal Monitoring: Regular monitoring of renal function recommended
5. HIV Screening: Test for HIV before initiation to prevent HIV resistance

Hilfo B Storage Conditions

Hilfo B Tablets require proper storage conditions:

• Store below 30°C in original container
• Keep the bottle tightly closed
• Protect from moisture
• Keep out of reach of children
• Do not use after expiration date