Hi-Sunate Ingredients and Usage

The active ingredient is Artesunate, a water-soluble hemisuccinate derivative of artemisinin. The 120mg vial is reconstituted and administered by intravenous or intramuscular injection, typically given at 0, 12, 24, and 48 hours, followed by a complete course of oral ACT (Artemisinin-based Combination Therapy).

Hi-Sunate is clinically indicated for:

• Severe and complicated malaria caused by Plasmodium falciparum
• Cerebral malaria with impaired consciousness
• Acute renal failure due to malaria
• Severe malarial anemia
• Patients who cannot tolerate oral medication

How Does Hi-Sunate Work?

Hi-Sunate provides rapid antimalarial action through multiple mechanisms:

1. Free Radical Generation: Produces free radicals that damage parasite membranes
2. Hemozoin Inhibition: Interferes with hemozoin formation in malaria parasites
3. Rapid Parasite Clearance: Achieves rapid reduction of parasite biomass within hours
4. Broad Stage Specificity: Effective against all erythrocytic stages of malaria parasites

Hi-Sunate Side Effects and Warnings

Common side effects include transient fever, chills, headache, nausea, dizziness, and injection site reactions. Most adverse effects are mild and self-limiting.

Serious Considerations

1. Hemolytic Anemia: May cause delayed hemolytic anemia after treatment
2. Allergic Reactions: Can cause hypersensitivity reactions including anaphylaxis
3. Cardiac Effects: May cause QT interval prolongation on ECG
4. Hepatic Impairment: Use with caution in patients with liver dysfunction
5. Pregnancy: Consider risk-benefit ratio in pregnant women with severe malaria

Hi-Sunate Storage Conditions

Hi-Sunate Injection requires proper storage conditions:

• Store unreconstituted vials below 30°C
• Protect from light and moisture
• Use reconstituted solution immediately
• Do not freeze reconstituted solution
• Discard unused portions appropriately