Heparin Sodium Ingredients and Usage

The active ingredient is Heparin Sodium, a highly sulfated glycosaminoglycan anticoagulant. The pre-filled syringe is administered by subcutaneous injection, typically in the abdominal fat layer, with dosage determined by the specific clinical indication and patient weight.

Heparin Sodium is clinically indicated for:

• Prophylaxis of deep vein thrombosis (DVT) and pulmonary embolism (PE)
• Treatment of established venous thromboembolism
• Prevention of clotting during surgical procedures
• Maintenance of catheter and intravenous line patency
• Treatment of unstable angina and myocardial infarction

How Does Heparin Sodium Work?

Heparin Sodium provides anticoagulant effects through antithrombin III activation:

1. Antithrombin III Activation: Binds to antithrombin III, accelerating its inhibitory activity
2. Coagulation Factor Inhibition: Inactivates thrombin (Factor IIa) and Factor Xa
3. Rapid Onset: Provides immediate anticoagulant effect after administration
4. Short Duration: Effects are reversible with protamine sulfate

Heparin Sodium Side Effects and Warnings

Common side effects include bleeding, heparin-induced thrombocytopenia, injection site reactions, and elevated liver enzymes. Most serious adverse effects are related to bleeding complications.

Serious Considerations

1. Heparin-Induced Thrombocytopenia: May cause HIT – monitor platelet counts regularly
2. Bleeding Risk: Significant risk of major bleeding – monitor coagulation parameters
3. Spinal Procedures: Increased risk of spinal hematoma with neuraxial anesthesia
4. Osteoporosis: Long-term use may cause bone density reduction
5. Allergic Reactions: May cause hypersensitivity reactions including anaphylaxis

Heparin Sodium Storage Conditions

Heparin Sodium Pre-filled Syringes require proper storage conditions:

• Store below 25°C protected from light
• Keep in original packaging until use
• Protect from freezing
• Use immediately after removing from packaging
• Do not use if discolored or contains particles