ManufacturerVarious Pharmaceutical Companies
Active IngredientsGlycopyrronium Bromide
Medicine Strength0.2mg per ml
FormulationSolution for Intravenous/Intramuscular Injection
Requires Prescription?Yes (Hospital Use – Physician prescription required)
GenericsGlycopyrrolate

Glycopyrrolate Ingredients and Usage

The active ingredient is Glycopyrronium Bromide, a synthetic quaternary ammonium anticholinergic agent. It is administered parenterally in doses of 0.1-0.2mg for secretion control or bradycardia treatment, with dosage adjusted based on clinical indication.

Glycopyrrolate is clinically indicated for:

  • Pre-anesthetic medication to reduce salivary and respiratory secretions
  • Intraoperative and postoperative bradycardia management
  • Peptic ulcer disease treatment
  • Chronic drooling in neurological disorders

How Does Glycopyrrolate Work?

Glycopyrrolate provides anticholinergic effects through muscarinic receptor blockade:

  1. Muscarinic Antagonism: Competitively blocks acetylcholine at muscarinic receptors
  2. Secretion Reduction: Inhibits glandular secretions including salivary and bronchial
  3. GI Motility Reduction: Decreases gastrointestinal motility
  4. Cardiac Effects: Increases heart rate by blocking vagal stimulation

Glycopyrrolate Side Effects and Warnings

Common side effects include dry mouth, blurred vision, urinary retention, constipation, and tachycardia.

Serious Considerations

  1. Glaucoma Risk: May precipitate acute angle-closure glaucoma
  2. Urinary Retention: Can cause urinary retention in elderly men with BPH
  3. Cardiac Conditions: Use with caution in patients with tachycardia or heart disease
  4. GI Obstruction: Contraindicated in mechanical intestinal obstruction

Glycopyrrolate Storage Conditions

Glycopyrrolate Injection requires proper storage:

  • Store at controlled room temperature 15-30°C
  • Protect from light and freezing
  • Keep in original container
  • Use only if solution is clear
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