Glandin E2 Ingredients and Usage

The active ingredient is Dinoprostone, a naturally occurring prostaglandin E2. The vaginal tablet is placed in the posterior fornix of the vagina, typically as a single 3mg dose, which may be repeated after 6-8 hours if necessary, under strict medical supervision.

Glandin E2 is clinically indicated for:

• Cervical ripening in pregnant women at or near term
• Labor induction in patients with medical or obstetric indications
• Preparation for surgical procedures requiring cervical dilation
• Termination of pregnancy in specific clinical situations

How Does Glandin E2 Work?

Glandin E2 facilitates cervical preparation through prostaglandin-mediated actions:

1. Cervical Softening: Promotes collagen breakdown and reorganization of cervical collagen fibers
2. Cervical Dilation: Stimulates cervical smooth muscle relaxation and dilation
3. Uterine Contractions: Initiates and enhances uterine contractility
4. Labor Initiation: Mimics natural prostaglandin effects that initiate labor

Glandin E2 Side Effects and Warnings

Common side effects include uterine hyperstimulation, nausea, vomiting, diarrhea, fever, and vaginal irritation. Most effects are related to the intended pharmacological action.

Serious Considerations

1. Uterine Hyperstimulation: May cause excessive uterine activity requiring immediate intervention
2. Fetal Distress: Can lead to non-reassuring fetal heart rate patterns
3. Contraindications: Not for use in patients with previous cesarean section or uterine surgery
4. Maternal Monitoring: Requires continuous fetal and maternal monitoring during administration
5. Uterine Rupture: Risk of uterine rupture, especially in multiparous women

Glandin E2 Storage Conditions

Glandin E2 Vaginal Tablets require strict storage conditions:

• Store at 2°C to 8°C in refrigerator
• Protect from light and moisture
• Keep in original foil packaging until use
• Bring to room temperature immediately before administration
• Do not use after expiration date