Gen-M Artesunate Ingredients and Usage

The active ingredient is Artesunate, a semi-synthetic derivative of artemisinin. The 60mg vial is reconstituted and administered by intravenous or intramuscular injection, typically given at 0, 12, 24, and 48 hours, followed by a complete course of oral ACT (Artemisinin-based Combination Therapy).

Gen-M Artesunate is clinically indicated for:

• Severe and complicated malaria caused by Plasmodium falciparum
• Cerebral malaria with impaired consciousness
• Acute renal failure due to malaria
• Severe malarial anemia
• Patients who cannot tolerate oral medication

How Does Gen-M Artesunate Work?

Gen-M Artesunate provides rapid antimalarial action through multiple mechanisms:

1. Parasite Killing: Generates free radicals that damage parasite membranes
2. Hemozoin Inhibition: Interferes with hemozoin formation in malaria parasites
3. Rapid Action: Achieves rapid reduction of parasite biomass within hours
4. Broad Stage Specificity: Effective against all erythrocytic stages of malaria parasites

Gen-M Artesunate Side Effects and Warnings

Common side effects include transient fever, chills, headache, nausea, and dizziness. Most adverse effects are mild and self-limiting.

Serious Considerations

1. Hemolytic Anemia: May cause delayed hemolytic anemia after treatment
2. Allergic Reactions: Can cause hypersensitivity reactions including anaphylaxis
3. Cardiac Effects: May cause QT interval prolongation on ECG
4. Hepatic Impairment: Use with caution in patients with liver dysfunction
5. Pregnancy: Consider risk-benefit ratio in pregnant women with severe malaria

Gen-M Artesunate Storage Conditions

Gen-M Artesunate Injection requires proper storage conditions:

• Store unreconstituted vials below 30°C
• Protect from light and moisture
• Use reconstituted solution immediately
• Do not freeze reconstituted solution
• Discard unused portions appropriately