Fulvedex Ingredients and Usage

The active ingredient is Fulvestrant, a selective estrogen receptor downregulator (SERD). It is administered as two 5ml (500mg total) intramuscular injections, one in each buttock, given once monthly on days 1, 15, and 29, then monthly thereafter.

Fulvedex is clinically indicated for:

• Hormone receptor-positive metastatic breast cancer in postmenopausal women
• Advanced breast cancer progressing after anti-estrogen therapy
• Combination therapy with palbociclib or abemaciclib for advanced breast cancer
• Patients with ESR1 mutations

How Does Fulvedex Work?

Fulvedex provides comprehensive estrogen receptor blockade through multiple mechanisms:

1. Estrogen Receptor Binding: Binds to estrogen receptors with affinity similar to estradiol
2. Receptor Downregulation: Accelerates degradation of estrogen receptor protein
3. Receptor Antagonism: Blocks estrogen-induced receptor activation and transcription
4. Tumor Growth Inhibition: Suppresses estrogen-dependent tumor cell proliferation

Fulvedex Side Effects and Warnings

Common side effects include injection site reactions, nausea, fatigue, hot flashes, joint pain, and headache. Most adverse effects are mild to moderate.

Serious Considerations

1. Injection Site Reactions: May cause pain, inflammation, and rarely, abscess formation
2. Hepatic Impairment: Use with caution in patients with moderate to severe hepatic impairment
3. Bleeding Risk: May increase prothrombin time in patients on coumarin anticoagulants
4. Pregnancy Risk: Contraindicated in pregnant women – can cause fetal harm
5. Bone Mineral Density: May accelerate bone loss in postmenopausal women

Fulvedex Storage Conditions

Fulvedex Injection requires proper storage conditions:

• Store at 2°C to 8°C in refrigerator
• Protect from light – keep in original carton
• Do not freeze
• Use immediately after removal from refrigerator
• Do not use if discolored or contains particles