Frusemide Ingredients and Usage

The active ingredient is Furosemide, a potent sulfonamide loop diuretic. The injection is administered intravenously or intramuscularly in doses titrated to clinical response, typically starting with 20-40mg, with careful monitoring of fluid and electrolyte status.

Frusemide is clinically indicated for:

• Acute pulmonary edema and congestive heart failure
• Edema associated with hepatic cirrhosis and renal disease
• Hypertensive emergencies when oral therapy not feasible
• Forced diuresis in certain drug intoxications

How Does Frusemide Work?

Frusemide provides potent diuresis through renal tubular action:

1. Loop of Henle Action: Inhibits sodium-potassium-chloride cotransporter in thick ascending limb
2. Water Excretion: Promotes excretion of water, sodium, chloride, and potassium
3. Venodilation: Causes immediate venodilation before diuretic effect in pulmonary edema
4. Fluid Reduction: Rapidly reduces extracellular fluid volume and preload

Frusemide Side Effects and Warnings

Common side effects include dehydration, electrolyte imbalance, hypotension, dizziness, and hearing disturbances. Most effects are dose-dependent and related to the diuretic action.

Serious Considerations

1. Electrolyte Depletion: May cause severe hypokalemia, hyponatremia, and hypochloremia
2. Ototoxicity: Can cause hearing loss, especially with rapid IV injection or high doses
3. Renal Impairment: May precipitate acute renal failure in susceptible patients
4. Hypotension: Can cause significant hypotension and circulatory collapse
5. Sulfa Allergy: Contraindicated in patients with sulfonamide allergy

Frusemide Storage Conditions

Frusemide Injection requires proper storage conditions:

• Store below 25°C protected from light
• Keep ampoules in original packaging
• Protect from freezing
• Use immediately after opening
• Do not use if discolored or contains particles