Exemestane Ingredients and Usage

The active ingredient is Exemestane, an irreversible steroidal aromatase inactivator. One 25mg tablet is taken once daily after a meal to enhance absorption and reduce gastrointestinal discomfort.

Exemestane is clinically indicated for:

• Early and advanced estrogen receptor-positive breast cancer in postmenopausal women
• Adjuvant treatment following 2-3 years of tamoxifen therapy
• First-line treatment of advanced hormone-dependent breast cancer
• Extended adjuvant therapy to prevent cancer recurrence

How Does Exemestane Work?

Exemestane provides anti-estrogen effects through aromatase enzyme inhibition:

1. Aromatase Inactivation: Irreversibly binds to and inactivates aromatase enzyme
2. Estrogen Synthesis Blockade: Prevents conversion of androgens to estrogen in peripheral tissues
3. Estrogen Level Reduction: Significantly lowers circulating estrogen levels
4. Tumor Growth Inhibition: Suppresses estrogen-dependent breast cancer cell proliferation

Exemestane Side Effects and Warnings

Common side effects include hot flashes, fatigue, joint pain, headache, insomnia, and increased sweating. Most side effects are mild to moderate and manageable.

Serious Considerations

1. Osteoporosis Risk: Accelerates bone mineral density loss – monitor bone health regularly
2. Cardiovascular Effects: May increase risk of cardiovascular events
3. Hepatic Impairment: Use with caution in patients with liver dysfunction
4. Drug Interactions: Avoid concomitant use with estrogen-containing therapies
5. Pregnancy Contraindication: Absolutely contraindicated in pregnant women

Exemestane Storage Conditions

Exemestane Tablets require proper storage conditions:

• Store below 25°C in original packaging
• Protect from moisture and light
• Keep blister strips sealed until use
• Keep out of reach of children
• Do not use after expiration date