Enbrel Ingredients and Usage

The active ingredient is Etanercept, a recombinant human TNF receptor fusion protein. The 50mg pre-filled syringe is administered as subcutaneous injection once weekly.

Enbrel is clinically indicated for:

• Moderate to severe rheumatoid arthritis
• Psoriatic arthritis and ankylosing spondylitis
• Plaque psoriasis in adult patients
• Juvenile idiopathic arthritis

How Does Enbrel Work?

Enbrel provides targeted immune modulation through TNF-alpha inhibition:

1. TNF-Alpha Binding: Competitively binds to tumor necrosis factor-alpha
2. Inflammatory Cascade Blockade: Prevents TNF-mediated inflammation
3. Cytokine Reduction: Decreases production of other inflammatory mediators
4. Immune System Modulation: Reduces autoimmune activity

Enbrel Side Effects and Warnings

Common side effects include injection site reactions, upper respiratory infections, and headache. Most reactions are mild to moderate.

Serious Considerations

1. Serious Infections: Increased risk of tuberculosis and opportunistic infections
2. Malignancy Risk: Higher incidence of lymphoma and other cancers
3. Neurological Events: Rare cases of demyelinating disorders
4. Heart Failure: May worsen congestive heart failure
5. Hematologic Events: Risk of pancytopenia and aplastic anemia

Enbrel Storage Conditions

Enbrel Pre-filled Syringes require specialized storage:

• Store refrigerated between 2°C and 8°C
• Do not freeze – protect from freezing temperatures
• Keep in original carton to protect from light
• Do not shake the pre-filled syringe
• Use immediately after removal from refrigerator