Efacurim Ingredients and Usage

The active ingredient is Fluconazole, a bis-triazole antifungal agent. The 50mg/5mL solution is administered as intravenous infusion over approximately 30-60 minutes.

Efacurim is clinically indicated for:

• Systemic candidiasis and cryptococcal meningitis
• Esophageal and oropharyngeal candidiasis
• Prophylaxis in immunocompromised patients
• Urinary tract and peritoneal fungal infections

How Does Efacurim Work?

Efacurim exerts antifungal activity through ergosterol synthesis inhibition:

1. Lanosterol Demethylase Inhibition: Blocks cytochrome P450 14α-demethylase
2. Ergosterol Depletion: Reduces essential fungal cell membrane component
3. Membrane Integrity Disruption: Causes increased permeability and cell death
4. Fungistatic Action: Inhibits fungal growth and replication

Efacurim Side Effects and Warnings

Common side effects include headache, nausea, abdominal pain, and skin rash. Most reactions are mild and self-limiting.

Serious Considerations

1. Hepatic Toxicity: Monitor liver function during prolonged therapy
2. QT Prolongation: May cause cardiac arrhythmias in susceptible patients
3. Drug Interactions: Multiple interactions with CYP450 metabolized drugs
4. Renal Impairment: Dose adjustment required in kidney dysfunction
5. Pregnancy Risk: Category D – avoid in first trimester

Efacurim Storage Conditions

Efacurim Injection requires proper storage handling:

• Store at room temperature below 25°C
• Protect from light and freezing
• Use opened vials immediately
• Discard if solution appears discolored or contains particles
• Keep out of reach of children