Edonax Ingredients and Usage

The active ingredient is Drotaverine Hydrochloride, a papaverine derivative antispasmodic. The 5mg/100mL solution is administered as slow intravenous infusion for acute spasms.

Edonax is clinically indicated for:

• Renal colic and ureteric spasm relief
• Biliary colic and gallbladder spasms
• Gastrointestinal smooth muscle spasms
• Gynecological spasms and dysmenorrhea

How Does Edonax Work?

Edonax provides smooth muscle relaxation through phosphodiesterase inhibition:

1. PDE-4 Inhibition: Selectively inhibits phosphodiesterase type 4 enzyme
2. cAMP Elevation: Increases intracellular cyclic adenosine monophosphate
3. Muscle Relaxation: Reduces calcium influx into smooth muscle cells
4. Selective Action: Primarily affects smooth muscle without cardiac effects

Edonax Side Effects and Warnings

Common side effects include hypotension, dizziness, headache, and injection site reactions. Most effects are mild and transient.

Serious Considerations

1. Hypotension Risk: May cause significant blood pressure drop
2. Cardiac Patients: Use with caution in severe heart failure
3. Hepatic Impairment: Dose adjustment needed in liver disease
4. Renal Function: Monitor in patients with kidney impairment
5. Pregnancy: Use only if clearly needed during pregnancy

Edonax Storage Conditions

Edonax Injection requires proper storage handling:

• Store at room temperature below 25°C
• Protect from light and freezing
• Use opened infusion bags immediately
• Discard if solution appears discolored or contains particles
• Keep out of reach of children