ManufacturerGlaxoSmithKline Pakistan
Active IngredientsDutasteride and Tamsulosin Hydrochloride
Medicine Strength0.5mg Dutasteride + 0.4mg Tamsulosin per Capsule
FormulationHard Gelatin Capsules
Requires Prescription?Yes (Urologist prescription required)
GenericsDutasteride + Tamsulosin

Duodart Ingredients and Usage

The active ingredients are Dutasteride (5-alpha reductase inhibitor) and Tamsulosin (alpha-1 blocker). The capsule is taken once daily after the same meal each day.

Duodart is clinically indicated for:

  • Moderate to severe benign prostatic hyperplasia
  • Patients with enlarged prostate and urinary symptoms
  • Combination therapy for BPH symptom relief
  • Reduction in risk of acute urinary retention

How Does Duodart Work?

Duodart provides dual mechanism action for comprehensive BPH management:

  1. Hormonal Effect: Dutasteride inhibits conversion of testosterone to DHT
  2. Prostate Shrinkage: Reduces prostate volume over 3-6 months
  3. Smooth Muscle Relaxation: Tamsulosin relaxes prostate and bladder neck
  4. Symptom Relief: Improves urine flow and reduces urinary symptoms

Duodart Side Effects and Warnings

Common side effects include ejaculation disorders, decreased libido, orthostatic hypotension, and dizziness. Most effects diminish with continued treatment.

Serious Considerations

  1. Prostate Cancer Screening: May lower PSA levels – adjust interpretation
  2. Orthostatic Hypotension: Risk of dizziness and syncope, especially initially
  3. Pregnancy Risk: Women should not handle crushed capsules
  4. Cataract Surgery: Inform surgeon about tamsulosin use
  5. Treatment Duration: Requires continuous long-term therapy for maintenance

Duodart Storage Conditions

Duodart Capsules require proper storage conditions:

  • Store at room temperature below 25°C
  • Keep in original packaging protected from moisture
  • Protect from light and excessive heat
  • Keep out of reach of children and women
  • Do not use after expiration date
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