Biodoce Ingredients and Usage

The active ingredient is Docetaxel, a taxane derived from European yew tree needles. The 80mg concentrate requires dilution before one-hour intravenous infusion every three weeks.

Biodoce is clinically indicated for:

• Metastatic breast cancer after anthracycline failure
• Non-small cell lung cancer
• Metastatic castration-resistant prostate cancer
• Gastric adenocarcinoma and head/neck cancer

How Does Biodoce Work?

Biodoce exerts cytotoxic effects through microtubule stabilization:

1. Microtubule Stabilization: Binds to tubulin promoting microtubule assembly
2. Mitotic Arrest: Blocks cell division at G2/M phase
3. Apoptosis Induction: Triggers programmed cell death in cancer cells
4. Anti-angiogenic Effects: Inhibits formation of new blood vessels in tumors

Biodoce Side Effects and Warnings

Common side effects include neutropenia, fluid retention, peripheral neuropathy, and nail changes. Most effects require premedication and supportive care.

Serious Considerations

1. Myelosuppression: Severe neutropenia requiring G-CSF support
2. Fluid Retention: Premedication with corticosteroids essential
3. Hypersensitivity Reactions: Premedication with antihistamines required
4. Hepatic Impairment: Dose reduction needed in liver dysfunction
5. Neurotoxicity: Cumulative peripheral sensory neuropathy

Biodoce Storage Conditions

Biodoce Injection requires specialized storage handling:

• Store refrigerated between 2°C and 8°C
• Protect from light and freezing
• Use diluted solution within 4 hours
• Discard if solution appears cloudy or contains particles
• Follow cytotoxic drug safety protocols