Deltoin Ingredients and Usage

The active ingredient is Phenytoin Sodium, a hydantoin derivative anticonvulsant. The 250mg injection is administered as slow intravenous infusion with cardiac monitoring.

Deltoin is clinically indicated for:

• Status epilepticus emergency treatment
• Acute seizure control when oral route unavailable
• Neurosurgical prophylaxis for seizures
• Loading dose for rapid therapeutic levels

How Does Deltoin Work?

Deltoin provides anticonvulsant effects through sodium channel modulation:

1. Sodium Channel Blockade: Stabilizes neuronal membranes
2. Seizure Threshold Elevation: Reduces neuronal excitability
3. Frequency-Dependent Action: Preferentially affects rapidly firing neurons
4. Calcium Influx Reduction: Modulates calcium channel activity

Deltoin Side Effects and Warnings

Common side effects include nystagmus, ataxia, slurred speech, and cardiovascular effects. Most reactions are dose-related and reversible.

Serious Considerations

1. Cardiac Monitoring: Risk of hypotension, bradycardia, and arrhythmias
2. Infusion Rate: Maximum 50mg per minute to prevent cardiovascular collapse
3. Extravasation Risk: Causes severe tissue injury and purple glove syndrome
4. Drug Interactions: Multiple interactions with other antiepileptics
5. Therapeutic Monitoring: Required due to nonlinear pharmacokinetics

Deltoin Storage Conditions

Deltoin Injection requires proper storage handling:

• Store at room temperature below 25°C
• Protect from light and freezing
• Use opened ampoules immediately
• Discard if solution appears cloudy or contains crystals
• Keep out of reach of children