Decibine Ingredients and Usage

The active ingredient is Decitabine, a cytidine nucleoside analogue DNA methyltransferase inhibitor. The 50mg powder requires reconstitution and administration as intravenous infusion over 1-3 hours.

Decibine is clinically indicated for:

• Myelodysplastic syndromes (MDS) treatment
• Acute myeloid leukemia (AML) in elderly patients
• Chronic myelomonocytic leukemia (CMML)
• High-risk MDS with excess blasts

How Does Decibine Work?

Decibine exerts antineoplastic effects through epigenetic modulation:

1. DNA Hypomethylation: Inhibits DNA methyltransferase enzyme
2. Gene Reactivation: Restores expression of silenced tumor suppressor genes
3. Cellular Differentiation: Promotes differentiation of malignant cells
4. DNA Incorporation: Incorporated into DNA leading to cytotoxic effects

Decibine Side Effects and Warnings

Common side effects include bone marrow suppression, nausea, fever, and fatigue. Most effects require careful monitoring and supportive care.

Serious Considerations

1. Myelosuppression: Severe neutropenia and thrombocytopenia risk
2. Infection Risk: Increased susceptibility to serious infections
3. Hepatic Toxicity: Monitor liver function during treatment
4. Renal Impairment: Use with caution in patients with kidney dysfunction
5. Pregnancy Risk: Teratogenic effects – effective contraception required

Decibine Storage Conditions

Decibine Injection requires specialized storage handling:

• Store at room temperature below 25°C
• Protect from light and moisture
• Use reconstituted solution within 15 minutes
• Discard if solution appears discolored or contains particles
• Follow cytotoxic drug safety protocols