Dasirox Ingredients and Usage

The active ingredient is Deferasirox, a tridentate oral iron chelating agent. The 250mg tablet is taken once daily on an empty stomach 30 minutes before food.

Dasirox is clinically indicated for:

• Chronic iron overload in transfusion-dependent patients
• Thalassemia major with iron accumulation
• Sickle cell disease patients requiring iron chelation
• Other chronic anemias with transfusion iron overload

How Does Dasirox Work?

Dasirox provides selective iron removal through specific chelation mechanisms:

1. Selective Iron Binding: High affinity for iron molecules
2. Complex Formation: Creates stable iron-deferasirox complexes
3. Biliary Excretion: Eliminates iron primarily through feces
4. Dose-Dependent Action: Chelation efficiency increases with dosage

Dasirox Side Effects and Warnings

Common side effects include nausea, diarrhea, abdominal pain, and skin rash. Most effects are mild to moderate and dose-dependent.

Serious Considerations

1. Renal Function: Monitor serum creatinine and creatinine clearance
2. Hepatic Monitoring: Regular liver function tests required
3. GI Complications: Risk of ulcers and gastrointestinal hemorrhage
4. Auditory Changes: Monitor for hearing loss and vision disturbances
5. Blood Tests: Regular serum ferritin and iron studies essential

Dasirox Storage Conditions

Dasirox Tablets require proper storage conditions:

• Store at room temperature below 30°C
• Keep in original blister packaging
• Protect from moisture and light
• Keep out of reach of children
• Do not use after expiration date