Darbazine Ingredients and Usage

The active ingredient is Dacarbazine, a synthetic purine analogue alkylating agent. The 200mg powder requires reconstitution and administration as intravenous infusion with light protection.

Darbazine is clinically indicated for:

• Metastatic malignant melanoma treatment
• Hodgkin lymphoma combination chemotherapy
• Soft tissue sarcomas in specific regimens
• Second-line therapy for various solid tumors

How Does Darbazine Work?

Darbazine exerts cytotoxic effects through alkylation and metabolic inhibition:

1. DNA Alkylation: Forms methyl carbonium ions that alkylate DNA
2. Purine Synthesis Inhibition: Interferes with purine nucleotide synthesis
3. Cell Cycle Arrest: Primarily affects G2 phase of cell division
4. Apoptosis Induction: Triggers programmed cell death in cancer cells

Darbazine Side Effects and Warnings

Common side effects include severe nausea, vomiting, bone marrow suppression, and flu-like symptoms. Most effects require intensive supportive care.

Serious Considerations

1. Photosensitivity: Requires strict light protection during administration
2. Myelosuppression: Regular complete blood count monitoring essential
3. Hepatic Toxicity: May cause liver enzyme elevation and hepatic necrosis
4. Anaphylaxis: Risk of hypersensitivity reactions during infusion
5. Extravasation: Causes severe tissue damage if leakage occurs

Darbazine Storage Conditions

Darbazine Injection requires specialized storage handling:

• Store refrigerated between 2°C and 8°C
• Protect from light at all times
• Use reconstituted solution immediately
• Discard if solution appears discolored
• Follow cytotoxic drug safety protocols