Colimate Ingredients and Usage

The active ingredient is Colistimethate Sodium, a polymyxin E antibiotic. The 1 MIU powder requires reconstitution for intravenous infusion or nebulizer administration.

Colimate is clinically indicated for:

• Multidrug-resistant Pseudomonas aeruginosa infections
• Carbapenem-resistant Enterobacteriaceae infections
• Ventilator-associated pneumonia treatment
• Cystic fibrosis pulmonary exacerbations

How Does Colimate Work?

Colimate provides bactericidal action through membrane disruption:

1. Membrane Permeabilization: Binds to bacterial outer membrane lipopolysaccharides
2. Cellular Content Leakage: Causes osmotic imbalance and cell death
3. Rapid Bacterial Killing: Exhibits concentration-dependent killing
4. Biofilm Penetration: Effective against biofilm-forming bacteria

Colimate Side Effects and Warnings

Common side effects include nephrotoxicity, neurotoxicity, and bronchospasm during inhalation. Most effects are dose-dependent and reversible.

Serious Considerations

1. Nephrotoxicity: Requires frequent renal function monitoring
2. Neuromuscular Blockade: May cause respiratory muscle weakness
3. Dosing Calculation: Based on ideal body weight and renal function
4. Drug Interactions: Enhanced toxicity with aminoglycosides
5. Loading Dose: Essential for achieving therapeutic levels quickly

Colimate Storage Conditions

Colimate Injection requires proper storage handling:

• Store below 25°C protected from light
• Use reconstituted solution within 24 hours if refrigerated
• Protect from moisture and freezing
• Discard if solution appears discolored or contains particles
• Follow strict aseptic preparation techniques